3998-04-7Relevant academic research and scientific papers
Design, synthesis and antifungal activity of carbazole derivatives
Zhu, Shi-Ping,Wang, Wen-Ya,Fang, Kun,Li, Zheng-Gang,Dong, Guo-Qiang,Miao, Zhen-Yuan,Yao, Jian-Zhong,Zhang, Wan-Nian,Sheng, Chun-Quan
, p. 229 - 233 (2014/02/14)
The incidence of invasive fungal infections is increasing rapidly. Clinically available antifungal agents suffer from limited efficacy and severe resistance. There is an urgent need to discover antifungal lead compounds with novel chemical scaffold. On the basis of our previously identified tetrahydrocarbazole antifungal leads, the structure-activity relationship was further explored by modifying the scaffold and the side chains. Several targeted compounds showed potent activity against Candida species. Particularly, compound 13i showed better antifungal activity than the lead compound, which can be used as a good starting point for further optimization.
Combined phase transfer catalysis and ultrasound to enhance tandem alkylation of azo dyes
Li, Xiang,Wang, Jie,Mason, Richard,Bu, Xiu R,Harrison, Joycelyn
, p. 3747 - 3753 (2007/10/03)
Ultrasound has been found to enhance N-substitution against elimination in the reaction of carbazole-containing bromides 3 with a Disperse Orange 3 derivative 2 under PTC condition. Upon using combined PTC and ultrasound conditions, a series of bifunctional molecules 1 have been prepared to possess charge-transporting agents and nonlinear optical chromophores in 2:1 ratio.
