40015-10-9

Basic information

• Product Name: 3-(METHYLTHIO)-1H-INDOLE
• Synonyms: 3-(METHYLTHIO)-1H-INDOLE
• CAS NO: 40015-10-9
• Molecular Formula: C₉H₉NS
• Molecular Weight: 163.23946
• Mol File: 40015-10-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(METHYLTHIO)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(METHYLTHIO)-1H-INDOLE(40015-10-9)
• EPA Substance Registry System: 3-(METHYLTHIO)-1H-INDOLE(40015-10-9)

Safety Data

• Hazardous Substances Data: 40015-10-9(Hazardous Substances Data)

Upstream product

• 109-89-7 diethylamine 
• 142-84-7 di-n-propylamine 
• 110-89-4 piperidine 
• 111-92-2 dibutylamine 
• 86915-11-9 3-methylsulfinyl-2-indolinone 

Downstream Products

• 1440957-47-0 2-bromo-3-methylthio-1-tosylindole 
• 1440957-40-3 ClO₄^(1-)*C₁₈H₂₀NO₂S₃⁽¹⁺⁾ 
• 1440957-38-9 3-(methylthio)-N-(p-toluenesulfonyl)indole 
• 582321-06-0 (1H-indol-3-yl)(methyl)-sulfoxide 
• 120-72-9 indole 
• 74422-05-2 methyl cis-exo-3-benzoyl-1,2,2a,7b-tetrahydro-3H-cyclobutindole-1-carboxylate 
• 90539-97-2 methyl exo-3-benzoyl-7b-methylthio-1,2,2a,7b-tetrahydro-3H-cyclobutindole-1-carboxylate 
• 108698-64-2 1-benzyl-2-chloro-3-methylsulfonylindole 
• 108726-69-8 1-benzyl-2-chloro-3-methylthioindole 
• 108698-58-4 N-benzyl-3-(methylsulfinyl)indole 
• 104501-77-1 1-benzyl-2-(methylthio)indole 
• 120517-33-1 2,3-bis(methylthio)indole 
• 116442-14-9 1-methyl-3-(methylthio)-1H-indole 
• 90539-83-6 1-benzoyl-3-methylthioindole 

Relevant articles and documents

A practical regioselective synthesis of alkylthio- or arylthioindoles without the use of smelly compounds such as thiols

A convenient method for the synthesis of 3-methylthioindoles has been established which does not use smelly compounds such as thiol derivatives. The method, which introduces an alkyl- or arylthio-group into the C3-position of the indole skeleton, was extended to the direct introduction of a methylthio or bromo group at the C2-position using 3-methylthioindoles. No dimerization occurred, and the reaction mechanism was confirmed. The products have the partial structure of potent anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) bromomethylthioindoles (MC 5-8) isolated from marine algae. Furthermore, this reaction could be applied to the synthesis of 3,3-diindolyl thioether which is a core structure of Echinosulfone A.