40068-81-3Relevant academic research and scientific papers
Catalytic α-Arylation of Imines Leading to N-Unprotected Indoles and Azaindoles
Marelli, Enrico,Corpet, Martin,Minenkov, Yury,Neyyappadath, Rifahath M.,Bismuto, Alessandro,Buccolini, Giulia,Curcio, Massimiliano,Cavallo, Luigi,Nolan, Steven P.
, p. 2930 - 2938 (2016/07/06)
A palladium N-heterocyclic carbene catalyzed methodology for the synthesis of substituted, N-unprotected indoles and azaindoles is reported. The protocol permits access to various, highly substituted members of these classes of compounds. Although two possible reaction pathways (deprotonative and Heck-like) can be proposed, control experiments, supported by computational studies, point toward a deprotonative mechanism being operative.
A novel one-step synthesis of 2-substituted 6-azaindoles from 3-amino-4-picoline and carboxylic esters
Song, Jinhua J.,Tan, Zhulin,Gallou, Fabrice,Xu, Jinghua,Yee, Nathan K.,Senanayake, Chris H.
, p. 6512 - 6514 (2007/10/03)
Dilithiation of 3-amino-4-picoline (1) was achieved with sec-BuLi at room temperature. Condensation of the resulting dianion (2) with carboxylic esters afforded a wide range of 2-substituted 6-azaindoles in good yields.
