400715-82-4

Basic information

• Product Name: methyl 1-methyl-5-phenyl-1H-pyrrole-2-carboxylate
• Synonyms: methyl 1-methyl-5-phenyl-1H-pyrrole-2-carboxylate
• CAS NO: 400715-82-4
• Molecular Weight: 215.252
• Mol File: 400715-82-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 1-methyl-5-phenyl-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-methyl-5-phenyl-1H-pyrrole-2-carboxylate(400715-82-4)
• EPA Substance Registry System: methyl 1-methyl-5-phenyl-1H-pyrrole-2-carboxylate(400715-82-4)

Safety Data

• Hazardous Substances Data: 400715-82-4(Hazardous Substances Data)

Upstream product

• 1008-89-5 2-phenylpyridine 
• 52806-02-7 iodure de 1-methyl-2-phenylpyridinium 
• 67-56-1 methanol 
• 137387-48-5 1-methyl-5-phenyl-1H- pyrrole-2-carboxaldehyde 
• 3042-22-6 2-phenyl-1H-pyrrole 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Lithium tert-butoxide-mediated carboxylation reactions of unprotected indoles and pyrroles with carbon dioxide

Unprotected indoles and pyrroles were found to undergo base-mediated carboxylation reactions under ambient pressure of carbon dioxide. It was found that this transition metal-free carboxylation reaction proceeded smoothly with the use of a large excess of LiOtBu.

The pyrrolecarboxylic acid production

PROBLEM TO BE SOLVED: To provide a novel production method of pyrrole carboxylic acids, with which carbon dioxide can be utilized as a carbon source and a pyrrole carboxylic acid useful as a production raw material of medicines and agrochemicals is easily produced by making 1H-pyrrole react with carbon dioxide so that a carboxy group is directly introduced into a pyrrole skeleton in a low pressure of 1 MPa or less.SOLUTION: In introducing a carboxy group into a pyrrole skeleton by directly carboxylating 1H-pyrrole with carbon dioxide in a reaction solvent and in the presence of a catalyst, an excess of basic catalyst over 1H-pyrrole is used as the catalyst so that a pyrrole carboxylic acid is produced by introducing a carboxy group into a pyrrole skeleton in a low pressure of 1 MPa or less. The basic catalyst is lithium t-butoxide.