52806-02-7

Basic information

• Product Name: 1-methyl-2-phenylpyridinium iodide
• CAS NO: 52806-02-7
• Molecular Formula: C₁₂H₁₂N*I
• Molecular Weight: 297.1349
• Mol File: 52806-02-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-phenylpyridinium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-phenylpyridinium iodide(52806-02-7)
• EPA Substance Registry System: 1-methyl-2-phenylpyridinium iodide(52806-02-7)

Safety Data

• Hazardous Substances Data: 52806-02-7(Hazardous Substances Data)

Usage

Chemical Family

1-methyl-2-phenylpyridinium iodide belongs to the family of pyridinium compounds.

Charge

It is a positively charged molecule due to the presence of the pyridinium group.

Research Use

Commonly used in research as a neurotoxin to study Parkinson's disease.

Neuronal Selectivity

It has been shown to selectively destroy dopaminergic neurons.

Biochemical and Pharmacological Studies

Used to understand the mechanisms of cell death and the neurotoxic effects of certain chemicals.

Organic Cation Transporter

It is a known substrate for the organic cation transporter.

Uptake and Accumulation

Its uptake and accumulation in cells have been extensively studied.

Solubility

1-methyl-2-phenylpyridinium iodide is a polar compound that is highly soluble in water and organic solvents, making it suitable for use in various experimental settings.

Upstream product

• 1008-89-5 2-phenylpyridine 
• 74-88-4 methyl iodide 
• 960-16-7 tributylphenylstannane 
• 52693-56-8 2-bromo-1-methyl-pyridinium iodide 
• 98-80-6 phenylboronic acid 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 144221-02-3 2-phenyl-6-(thiophen-2-yl)pyridine 
• 1030918-01-4 2-phenyl-6-(thiophen-3-yl)pyridine 
• 1146731-94-3 2-(4-nitrophenyl)-6-phenylpyridine 
• 828-80-8 1,2-dimethyl-5-phenyl-1H-pyrrole 
• 400715-82-4 methyl 1-methyl-5-phenyl-1H-pyrrole-2-carboxylate 
• 137387-48-5 1-methyl-5-phenyl-1H- pyrrole-2-carboxaldehyde 

Relevant articles and documents

Influence of the anion nature and alkyl substituents in the behavior of ionic liquids derived from phenylpyridines

Quaternary alkyl 2-phenylpyridinium and 2-(2,4-difluorophenyl)pyridinium amines with iodide, hexafluorophosphate and bis(trifluoromethylsulfonyl)imide anions have been fully characterized by 1H NMR, FT-IR and MALDI mass spectroscopic methods an

Synthesis of 2-Formylpyrroles from Pyridinium Iodide Salts

The first I2-mediated synthesis of 2-formylpyrroles from pyridinium salts is reported. This protocol enables the synthesis of diversely substituted 2-formylpyrroles in good yields under operationally simple conditions. The detailed mechanistic studies reveal that the reaction proceeds via a novel H2O-triggered ring opening of the pyridinium salt and a subsequent intramolecularly nucleophilic addition sequence.

Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes

The first Pd/Cu catalyzed selective C2-alkenylation of pyridines with internal alkynes has been developed via the pyridinium salt activation strategy. Importantly, the configuration of the product alkenylpyridines could be tuned by the choice of the proper N-alkyl group of the pyridinium salts, thus allowing for both the Z- and E-alkenylpyridines synthesized with good regio- and stereoselectivity. A plausible mechanism was proposed based on the Hammett study and KIE experiment.