400747-22-0

Usage

Uses

Methyl 4''-aminobiphenyl-3-carboxylate

Upstream product

• 107558-26-9 methyl 4'-nitro-[1,1'-biphenyl]-3-carboxylate 
• 729-01-1 4'-nitrobiphenyl-3-carboxylic acid 
• 25487-66-5 3-Carboxyphenylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 99769-19-4 [3-(methoxycarbonyl)phenyl]boronic acid 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 910651-42-2 4'-[3-(4-tert-butyl-phenyl)-propionylamino]-biphenyl-3-carboxylic acid methyl ester 
• 1295649-86-3 4′-(α-D-mannopyranosylamino)-[1,1′biphenyl]-3-carboxylic acid methyl ester 
• 1295649-88-5 4′-[(α-D-mannopyranosylcarbonyl)amino]-[1,1′-biphenyl]-3-carboxylic acid methyl ester 
• 1360630-30-3 methyl 4'-(2-naphthamido)biphenyl-3-carboxylate 
• 1360630-51-8 methyl 4'-(naphthalene-2-sulfonamido)biphenyl-3-carboxylate 
• 1360630-55-2 methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxylate 
• 1360630-50-7 methyl 4'-(6-amino-2-naphthamido)biphenyl-3-carboxylate 
• 1360630-49-4 methyl 4'-(6-bromo-2-naphthamido)biphenyl-3-carboxylate 
• 1360630-48-3 methyl 4'-(6-chloro-2-naphthamido)biphenyl-3-carboxylate 
• 1360630-41-6 methyl 4'-(6-methoxy-2-naphthamido)biphenyl-3-carboxylate 
• 1360630-40-5 4'-(6-cyano-2-naphthamido)biphenyl-3-carboxylic acid 
• 1360630-39-2 methyl 4'-(6-cyano-2-naphthamido)biphenyl-3-carboxylate 
• 1360630-32-5 methyl 4'-(6-carbamoyl-2-naphthamido)biphenyl-3-carboxylate 
• 864075-94-5 methyl 4'-[(4-{[4-(4-butoxycarbonylamino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]biphenyl-3-carboxylate 

Relevant academic research and scientific papers

Bifunctional Naphtho[2,3- d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects in Vitro and in Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

Human dihydroorotate dehydrogenase (hDHODH) is an attractive target for cancer therapy. Based on its crystal structure, we designed and synthesized a focused compound library containing the structural moiety of 1,4-benzoquinone, which possesses reactive oxygen species (ROS) induction capacity. Compound 3s with a naphtho[2,3-d][1,2,3]triazole-4,9-dione scaffold exhibited inhibitory activity against hDHODH. Further optimization led to compounds 11k and 11l, which inhibited hDHODH activity with IC50 values of 9 and 4.5 nM, respectively. Protein-ligand cocrystal structures clearly depicted hydrogen bond and hydrophobic interactions of 11k and 11l with hDHODH. Compounds 11k and 11l significantly inhibited leukemia cell and solid tumor cell proliferation and induced ROS production, mitochondrial dysfunction, apoptosis, and cell cycle arrest. Nanocrystallization of compound 11l displayed significant in vivo antitumor effects in the Raji xenograft model. Overall, this study provides a novel bifunctional compound 11l with hDHODH inhibition and ROS induction efficacy, which represents a promising anticancer lead worthy of further exploration.

Mimics of Pincer Ligands: An Accessible Phosphine-Free N-(Pyrimidin-2-yl)-1,2-azole-3-carboxamide Framework for Binuclear Pd(II) Complexes and High-Turnover Catalysis in Water

We report for the first time cyclic phosphine-free "head to tail"N,N,N pincer-like (pincer complexes mimicking) N-(pyrimidin-2-yl)-1,2-azole-3-carboxamide Pd(II) complexes with deprotonated amide groups as high-turnover catalysts (TON up to 106, TOF up to 1.2 × 107 h-1) for cross-coupling reactions on the background of up to quantitative yields under Green Chemistry conditions. The potency of the described catalyst family representatives was demonstrated in Suzuki-Miyaura, Mizoroki-Heck, and Sonogashira reactions on industrially practical examples. Corresponding ligands could be synthesized based on readily available reagents through simple chemical transformations. Within the complex structures, a highly unusual 1,3,5,7-tetraza-2,6-dipalladocane frame could be observed.

Triazole naphthoquinone connected aromatic (heterocyclic) ring derivative

The invention belongs to the field of chemical medicine, particularly relates to a micromolecule capable of resisting malignant tumor, acute leukemia and arthritis, multiple sclerosis and immunological rejection and a preparation and application of the mi

Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)

Recent drug discovery programs targeting urokinase plasminogen activator (uPA) have resulted in nonpeptidic inhibitors consisting of amidine or guanidine functional groups attached to aromatic or heteroaromatic scaffolds. There is a general problem of poor oral bioavailability of these charged inhibitors. In this paper, we report the synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as uPA inhibitors containing non-basic groups as substitute for amidine or guanidine groups.

Biaryl derived amide modulators of vanilloid VR1 receptor

The invention is directed to novel vanilloid receptor type 1 (VR1) ligands. More specifically, the invention relates to novel biaryl-derived amides that are potent antagonists or agonists of VR1. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

AMINO ACIDS

Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.