4010-22-4

Usage

Chemical compound

2-acetyl-4-methylphenyl 4-chlorobenzoate

Common uses

flavoring agent, fragrance ingredient

Derived from

2-acetyl-4-methylphenol and 4-chlorobenzoic acid

Physical form

white crystalline solid

Odor

sweet, fruity, floral

Applications

perfumes, cosmetics, food products, pharmaceuticals, organic synthesis

Chemical structure

benzene ring with acetyl group, methyl group, chlorobenzoate group

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 122-01-0 4-chloro-benzoyl chloride 
• 106-43-4 para-chlorotoluene 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 60402-30-4 2-(4-chlorophenyl)-6-methyl-4H-chromen-4-one 
• 136764-54-0 1a,7a-Dihydro-5-methyl-1a-(4-chlorophenyl)-7H-oxireno<1>benzopyran-7-one 
• 1351986-49-6 2-(4-chlorobenzoyloxy)-5-methyl-benzoylmethyltriphenylphosphonium bromide 
• 4238-38-4 1-[2-(4-chlorobenzoyloxy)-5-methylphenyl]-2-bromoethanone 
• 60402-29-1 1-(4-Chloro-phenyl)-3-(2-hydroxy-5-methyl-phenyl)-propane-1,3-dione 

Relevant academic research and scientific papers

Directing group assisted copper-catalyzed chemoselective O-aroylation of phenols and enols using alkylbenzenes

By using alkylbenzenes as aroyl surrogates, copper(II) catalyzed chemoselective O-aroylations of 1,3-dicarbonyl compounds and phenolic-OH ortho to carbonyl (-CHO,-COR) groups have been achieved. A dual mechanism operating in tandem for these transformations has been supported by a crossover experiment.

A new synthesis of flavones and pyranoflavone by intramolecular photochemical Wittig reaction in water

A new synthetic approach toward the synthesis of flavones and pyranoflavone has been developed by light induced intramolecular photochemical Wittig reaction in water onto aryloxycarbonyl groups and suitably substituted phosphonium bromides sans any phase transfer catalyst or promoter.

Epoxidation of Flavones by Dimethyldioxirane

The synthesis of epoxides 2 by epoxidation of flavones 1 with isolated dimethyldioxirane (as acetone solution) at subambient temperatures is reported.These labile epoxides were isolated and completely characterized by UV, IR, 1H and 13C NMR, MS, and C,H analyses.Warming to room temperature led to rearrangement to afford quantitatively the 3-hydroxyflavones 3b,h,i,n.Treatment of the epoxides 2b,f with methanol led to the 3-hydroxy-2-methoxyflavanones 4b,f, as a mixture of cis and trans isomers.