40108-63-2Relevant academic research and scientific papers
Dodecanoyl thiosemicarbazide derivatives as useful synthons in the synthesis of 1,2,4-triazole, 1,3,4-thiadiazole, and 1,3-benzothiazole derivatives
Hemdan, Magdy M.,Abou Elmagd, Wael S. I.,Samy, Sandy S.,Youssef, Ahmed S. A.
, p. 710 - 718 (2016)
A convenient synthesis of the dodecanoyl thiosemicarbazide derivatives 3a, b has been achieved from the reaction of 2-benzamido-3-arylacryloylhydrazides 1a, b and lauroyl isothiocyanate (2). The thiosemicarbazide derivative 3a is used as precursor for syn
Core-Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties
Gagnot, Glwadys,Hervin, Vincent,Coutant, Eloi P.,Goyard, Sophie,Jacob, Yves,Rose, Thierry,Hibti, Fatima Ezzahra,Quatela, Alessia,Janin, Yves L.
supporting information, p. 2112 - 2123 (2020/12/18)
In this work on the design and studies of luciferins related to the blue-hued coelenterazine, the synthesis of heterocyclic analogues susceptible to produce a photon, possibly at a different wavelength, is undertaken. Here, the synthesis of O-acetylated derivatives of imidazo[1,2-b]pyridazin-3(5 H)-one, imidazo[2,1-f][1,2,4]triazin-7(1 H)-one, imidazo[1,2-a]pyridin-3-ol, imidazo[1,2-a]quinoxalin-1(5 H)-one, benzo[f]imidazo[1,2-a]quinoxalin-3(11 H)-one, imidazo[1′,2′:1,6]pyrazino[2,3-c]quinolin-3(11 H)-one, and 5,11-dihydro-3 H-chromeno[4,3-e]imidazo[1,2-a]pyrazin-3-one is described thanks to extensive use of the Buchwald–Hartwig N-arylation reaction. The acidic hydrolysis of these derivatives then gave solutions of the corresponding luciferin analogues, which were studied. Not too unexpectedly, even if these were “dressed” with substituents found in actual substrates of the nanoKAZ/NanoLuc luciferase, no bioluminescence was observed with these compounds. However, in a phosphate buffer, all produced a light signal, by chemiluminescence, with extensive variations in their respective intensity and this could be increased by adding a quaternary ammonium salt in the buffer. This aspect was actually instrumental to determine the emission spectra of many of these luciferin analogues.
Synthesis of Novel Heterocycles Derived from 4-Arylmethylene-2-phenyl-1,3-oxazole-5(4H)-ones
Youssef, Ahmed S. A.,Kandeel, Kamal A.,Abou-Elmagd, Wael S.I.,Haneen, David S. A.
, p. 809 - 816 (2016/05/19)
The acid hydrazide derivatives 2 were converted into pyrazolone, triazinone, and schiff bases. However, the reaction of Schiff base 12 with malononitrile or thioglycolic acid gives the pyrazolotriazinone or thiazolidinone derivative, respectively. The str
Design, synthesis, and biological evaluation of hydrazone incorporated 1,2,4-triazines as anticonvulsant agents
Amir, Mohammed,Ali, Israr,Hassan, Mohd. Zaheen,Mulakayala, Naveen
, p. 958 - 968 (2015/02/19)
New hydrazone incorporated triazines were designed and synthesized using an appropriate synthetic route with regard to essential pharmacophores, and evaluated for their anticonvulsant activity through maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole-induced seizure (scPTZ) screenings. Among the tested compounds, 4-[{2-(5-(3-chlorobenzyl)-3-phenyl-1,2,4-triazine-6-yl)hydrazono} methyl]-N,N-dimethylaniline 6k (MES ED50 54.31, scPTZ ED50 92.01) and 4-[{2-(5-(4-chlorobenzyl)-3-phenyl-1,2,4-triazine-6-yl)hydrazono}methyl]-N,N-dimethylaniline 6r (MES ED50 46.05, scPTZ ED50 83.90) emerged as the most active anticonvulsant agents having GABAergic effects. Compounds 6k and 6r also showed lesser CNS depressant effect than the standard drug carbamazepine. To obtain further insights into the binding interactions of these molecules, molecular docking studies were carried out.
Synthesis and evaluation of N-(α-benzamido cinnamoyl) aryl hydrazone derivatives for anti-inflammatory and antioxidant activities
Rajitha,Saideepa,Praneetha
experimental part, p. 729 - 733 (2011/07/29)
A series of novel N-(α-benzamido cinnamoyl) aryl hydrazone derivatives 3a-m have been synthesized and screened for their anti-inflammatory and antioxidant activities. These compounds have been synthesized by refluxing intermediate α-benzamidocinnamhydrazi
Synthesis and reactions of imidazolinones and triazolotriazines
Badr, Mahmoud Zarif Amin,Mahgoub, Safaa Abd El-Salam
, p. 829 - 837 (2007/10/02)
4-Arylidene-2-phenyl-2-imidazoline-5-thiones (2) react with alkyl halides and ethyl chloroacetate in EtONa to give alkylthioimidazoles (3).The chalcones (5) obtained from the reaction of 4-arylidene-2-phenyl-1-(p-phenacetyl)-2-imidazolin-5-ones (4) and ar
