4013-71-2

Basic information

• Product Name: PYRIDINE-2-CARBONYL AZIDE
• Synonyms: PYRIDINE-2-CARBONYL AZIDE
• CAS NO: 4013-71-2
• Molecular Formula: C₆H₄N₄O
• Molecular Weight: 148.12
• Mol File: 4013-71-2.mol
• Article Data: 21

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: PYRIDINE-2-CARBONYL AZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE-2-CARBONYL AZIDE(4013-71-2)
• EPA Substance Registry System: PYRIDINE-2-CARBONYL AZIDE(4013-71-2)

Safety Data

• Hazardous Substances Data: 4013-71-2(Hazardous Substances Data)

Usage

General Description

PYRIDINE-2-CARBONYL AZIDE, also known as 2-pyridinecarboxylic acid azide, is a chemical compound with the molecular formula C7H5N5O. It is a highly reactive compound with a pale yellow color and is known to be an explosive material. It is commonly used in organic synthesis as a reagent for the formation of heterocycles and in the production of dyes, pharmaceuticals, and agricultural chemicals. However, it is important to handle this compound with caution due to its explosive nature and potential hazards. Overall, PYRIDINE-2-CARBONYL AZIDE is a versatile chemical that is utilized in various applications within the chemical and pharmaceutical industries.

InChI:InChI=1/C6H5N4O/c7-10-9-6(11)5-3-1-2-4-8-5/h1-4,7H/q+1

Upstream product

• 144223-29-0 1H-1,2,3-benzotriazol-1-yl(2-pyridinyl)methanone 
• 98-98-6 2-Picolinic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 1452-63-7 picolinic acid hydrazide 
• 2524-52-9 ethyl-2-picolinate 
• 1121-60-4 pyridine-2-carbaldehyde 
• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 40086-66-6 2-Bromoacetylpyridine 
• 29745-44-6 pyridine-2-carbonyl chloride 

Downstream Products

• 93598-47-1 3-benzoyl-2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one 
• 167402-17-7 pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yloxy]-ethyl ester 
• 167402-12-2 pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-2-isopropyl-5-(2-methoxy-phenoxy)-pyrimidin-4-yloxy]-ethyl ester 
• 167402-13-3 pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2-propyl-pyrimidin-4-yloxy]-ethyl ester 
• 167402-15-5 pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-2-cyclopropyl-5-(2-methoxy-phenoxy)-pyrimidin-4-yloxy]-ethyl ester 
• 167402-16-6 pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonyl-amino)-5-(2-methoxy-phenoxy)-2-thiophen-2-yl-pyrimidin-4-yloxy]-ethyl ester 
• 179400-71-6 pyridin-2-yl-carbamic acid 2-[6-(5-isopropyl-pyridine-2-sulfonylamino)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yloxy]-ethyl ester 
• 1017609-99-2 C₁₄H₁₂N₂O 

Relevant articles and documents

Redetermination and Density Functional Studies of N,N′-(Disulfanediyldibenzene-2,1-Diyl) Dipyridine-2-Carboxamide

The title compound C24H18N4O2S2 is synthesized via the azide method and its structure is redetermined at 100(2) K. The title structure, N,N′-(disulfanediyldibenzene-2,1-diyl)dipyridine-2-carboxamide i

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors

Abstract An efficient synthetic strategy was developed to modulate the structure of the tetrahydropyridine isoindolone (Valmerin) skeleton. A library of more than 30 novel final structures was generated. Biological activities on CDK5 and GSK3 as well as cellular effects on cancer cell lines were measured for each novel compound. Additionally docking studies were performed to support medicinal chemistry efforts. A strong GSK3/CDK5 dual inhibitor (38, IC50 GSK3/CDK5 32/84 nM) was obtained. A set of highly selective GSK3 inhibitors was synthesized by fine-tuning structural modifications (29 IC50 GSK3/CDK5 32/320 nM). Antiproliferative effects on cells were correlated with the in vitro kinase activities and the best effects were obtained with lung and colon cell lines.

Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction

A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.

Synthesis of: N -methylated amines from acyl azides using methanol

The transformation of acyl azide derivatives into N-methylamines was developed using methanol as the C1 source via the one-pot Curtius rearrangement and borrowing hydrogen methodology. Following this protocol, various functionalised N-methylated amines were synthesized using the (NNN)Ru(ii) complex from carboxylic acids via an acyl azide intermediate. Several kinetic studies and DFT calculations were carried out to support the mechanism and also to determine the role of the Ru(ii) complex and base in this transformation.