401648-34-8Relevant academic research and scientific papers
A microwave-assisted, copper-catalyzed three-component synthesis of dihydropyrimidinones under mild conditions
Pasunooti, Kalyan Kumar,Chai, Hua,Jensen, Chantel Nixon,Gorityala, Bala Kishan,Wang, Siming,Liu, Xue-Wei
supporting information; experimental part, p. 80 - 84 (2011/02/25)
The synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction under microwave irradiation is reported. The copper-catalyzed process proved to be simple, efficient, economical, and environmentally friendly.
First application of hexaaquaaluminium(III) tetrafluoroborate as a mild, recyclable, non-hygroscopic acid catalyst in organic synthesis: a simple and efficient protocol for the multigram scale synthesis of 3,4-dihydropyrimidinones by Biginelli reaction
Litvi?, Mladen,Ve?enaj, Ivana,Ladi?i?, Zrinka Mikulda?,Lovri?, Marija,Vinkovi?, Vladimir,Filipan-Litvi?, Mirela
experimental part, p. 3463 - 3471 (2010/06/17)
For the first time hexaaquaaluminium(III) tetrafluoroborate has been used as a mild acid catalyst in organic synthesis. A simple method of its preparation based on the reaction of aluminium triisopropoxide and tetrafluoroboric acid in isopropanol afforded
Magnesium/methanol: an effective reducing agent for chemoselective reduction of pyrimidine-2(1H)-ones
Singh, Kamaljit,Singh, Kawaljit
supporting information; experimental part, p. 2219 - 2221 (2009/08/07)
Magnesium in methanol is an effective reagent for the chemoselective reduction of pyrimidine-2(1H)-ones. Other reducible functionalities such as ester and alkene of enamine ester and uriedo carbonyl remain unaffected. This constitutes the first example of
Metalation of Biginelli compounds. A general unprecedented route to C-6 functionalized 4-aryl-3,4-dihydropyrimidinones
Singh, Kamaljit,Singh, Sukhdeep,Mahajan, Aman
, p. 6114 - 6117 (2007/10/03)
4-Aryl-6-methyl-3,4-dihydro-2(1H)-pyrimidinone esters (DHPMs) readily undergo metalation at the C-6 methyl (vinylogous ester) position on treatment with lithium diisopropylamide at -10 °C. The resulting anion intermediates can be treated with electrophili
