448-36-2

Basic information

• Product Name: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOIC ACID
• Synonyms: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOIC ACID;RARECHEM AL BO 0994;2-Carboxy-5-(trifluoromethyl)anisole, 4-Carboxy-3-methoxybenzotrifluoride, 4-(Trifluoromethyl)-o-anisic acid
• CAS NO: 448-36-2
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.15
• Mol File: 448-36-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 125-130℃
• Appearance: /
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOIC ACID(448-36-2)
• EPA Substance Registry System: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOIC ACID(448-36-2)

Safety Data

• Hazardous Substances Data: 448-36-2(Hazardous Substances Data)

Usage

Uses

2-Methoxy-4-(trifluoromethyl)benzoic acid is used as a synthetic building block.

Upstream product

• 325-36-0 2-allyl-5-trifluoromethyl-anisole 
• 286441-66-5 methyl 2-methoxy-4-(trifluoromethyl)benzoate 
• 10049-21-5 sodium dihydrogenphosphate 
• 132927-09-4 2-methoxy-4-(trifluoromethyl)benzaldehyde 
• 618-05-3 2-propyl-5-(trifluoromethyl)phenol 
• 402-05-1 2-bromo-5-(trifluoromethyl)phenol 
• 585-49-9 1-(prop-2-en-1-yloxy)-3-(trifluoromethyl)benzene 
• 98-17-9 3-Trifluoromethylphenol 
• 582-14-9 2-propyl-5-trifluoromethyl-anisole 
• 402-07-3 1-bromo-2-methoxy-4-(trifluoromethyl)benzene 

Downstream Products

• 95420-55-6 2-(2-Methoxy-4-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine; hydrochloride 
• 1208984-79-5 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid 
• 1276591-27-5 2-methoxy-N-(5-nitrothiazol-2-yl)-4-(trifluoromethyl)benzamide 
• 1613134-53-4 1-[2-(2-methoxy-4-trifluoromethylbenzoylamino)ethyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 1613253-90-9 methyl 1-(2-(2-methoxy-4-(trifluoromethyl)benzamido)ethyl)-1H-imidazole-4-carboxylate 
• 1613253-51-2 5-[2-(2-methoxy-4-trifluoromethyl-benzoylamino)-ethyl]-2H-[1,2,4]triazole-3-carboxylic acid [cyano-(4-ethyl-phenyl)-methyl]-amide 
• 1613253-79-4 1-[3-(2-methoxy-4-trifluoromethyl-benzoylamino)-propyl]-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 1316830-64-4 2-methoxy-6-methylsulfanyl-N-(4-oxo-tetrahydro-pyran-3-yl)-4-trifluoromethyl-benzamide 
• 1316830-62-2 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-N-(1,4,8-trioxa-spiro[4.5]dec-6-yl)-benzamide 

Relevant articles and documents

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: Assessment of potency, efficacy, and cardiovascular safety

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against the chosen cardiovascular endpoints at high drug concentrations in the plasma and brain. Optimization of this series led to considerable improvements in affinity, functional potency, and pharmacokinetic profile. This led to the identification of a 7-fluorochromone-2-carboxamide (22) that was orally efficacious in a diet-induced obese mouse model, retained a favorable cardiovascular profile in rat, and demonstrated dramatic improvement in effects on mean arterial pressure in our dog cardiovascular model compared to other series reported by our group. However, this analogue also led to prolongation of the QT interval in the dog that was linked to affinity for hERG channel and unexpectedly potent functional blockade of this ion channel.