783-79-9

Upstream product

• 917-64-6 methyl magnesium iodide 
• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 13329-40-3 4-Iodoacetophenone 
• 120120-26-5 (trifluoromethyl)triethylsilane 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 75-46-7 trifluoromethan 
• 111991-14-1 2-(4-trifluoromethylphenyl)oxirane 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 133512-61-5 1,1,1-trifluoro-2-(4-iodophenyl)propan-2-ol 

Downstream Products

• 122243-16-7 3-Nitro-benzenesulfonic acid 2,2,2-trifluoro-1-methyl-1-(4-trifluoromethyl-phenyl)-ethyl ester 
• 76954-03-5 1-(4-trifluoromethylphenyl)-1-(trifluoromethyl)ethyl tosylate 

Relevant academic research and scientific papers

Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: The beneficial anchoring effect of borates

Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of different aromatic and heteroaromatic iodides.

Organocatalysis approach to trifluoromethylation with fluoroform

The organic base methodology exploits an access to generate the "trifluoromethyl anion" for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation products were obtained efficiently.

Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers

A new strategy towards [18F]trifluoromethyl-containing compounds is developed. [18F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [18/sup

A NOVEL AND CONVENIENT METHOD FOR TRIFLUOROMETHYLATION OF ORGANIC HALIDES USING CF3SiR'3/KF/Cu(I) SYSTEM

Fluoride ion induced cross-coupling reaction of organic halides with trifluoromethyltrialkylsilanes takes place in the presence of Cu(I) salts under mild reaction conditions to give the corresponding trifluoromethylated products in high yields.

Solvolytic Studies of the Highly Deactivated 1-Aryl-1-(trifluoromethyl)ethyl Tosylates

The rates of solvolysis of 1-aryl-1-(trifluoromethyl)ethyl tosylates 1b-i and 1-aryl-1-(trifluoromethyl)ethyl bromides 3a,b in 80percent ethanol, and of 1-phenyl- and 1-(3-chlorophenyl)-1-(trifluoromethyl)ethyl tosylates (1e and 1g) in a variety of solven

SOLVOLYSIS OF 1-ARYL-1-(TRIFLUOROMETHYL)ETHYL TOSYLATES. EVIDENCE FOR AN EXTREMELY HIGH ELECTRON DEMAND CARBENIUM ION INTERMEDIATE DUE TO THE PRESENCE OF α-TRIFLUOROMETHYL SUBSTITUENT

The rate-retarding effect of α-trifluoromethyl group observed in the solvolysis of 1-aryl-1-(trifluoromethyl)ethyl tosylates is so profound that a very large negative ρ+ value, -8.82, is resulted and the 1-phenyl derivative becomes even less re