783-79-9Relevant articles and documents
Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: The beneficial anchoring effect of borates
Gonda, Zsombor,Kovacs, Szabolcs,Weber, Csaba,Gati, Tamas,Meszaros, Attila,Kotschy, Andras,Novak, Zoltan
supporting information, p. 4268 - 4271 (2014/09/30)
Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of different aromatic and heteroaromatic iodides.
Organocatalysis approach to trifluoromethylation with fluoroform
Zhang, Yuan,Fujiu, Motohiro,Serizawa, Hiroki,Mikami, Koichi
supporting information, p. 367 - 371 (2014/01/06)
The organic base methodology exploits an access to generate the "trifluoromethyl anion" for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation products were obtained efficiently.
Substituent effects. XIX. Solvolysis of 1-aryl-1-(trifluoromethyl)ethyl tosylates
Murata,Goto,Fujiyama,Mishima,Fujio,Tsuno
, p. 1129 - 1137 (2007/10/02)
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