40240-72-0

Basic information

• Product Name: (E)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4- dione
• Synonyms: (E)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4- dione
• CAS NO: 40240-72-0
• Molecular Weight: 266.296
• Mol File: 40240-72-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4- dione(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4- dione(40240-72-0)
• EPA Substance Registry System: (E)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4- dione(40240-72-0)

Safety Data

• Hazardous Substances Data: 40240-72-0(Hazardous Substances Data)

Upstream product

• 530-48-3 1,1-Diphenylethylene 
• 5700-44-7 1-phenyl-1-cyclohexylethylene 
• 19523-28-5 1-methyl-4-(2-phenyl-2-prop-2-ene-1-sulfonyl)-benzene 
• 128318-85-4 1-(1-azidoprop-2-en-2-yl)benzene 
• 16307-59-8 N-(2-phenyl-2-propenyl)phthalimide 
• 1374016-46-2 N-(2-phenylallyl)-N-(phenylsulfonyl)benzenesulfonamide 
• 56865-72-6 2-Phenyl-3-(phenylamino)-1-propene 
• 86148-32-5 2-phenyl-2-propen-1-ol benzoate 
• 1231245-70-7 C₁₅H₁₃Cl 
• 93273-60-0 1-methoxy-3-(2-phenylallyl)benzene 
• 1433269-77-2 methyl 4-(2-phenylallyl)benzoate 
• 948-97-0 2,3-diphenyl-1-propene 
• 140156-00-9 1-methyl-4-(2-phenylallyl)benzene 

Downstream Products

• 144774-54-9 (Z)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4-dione 
• 60755-22-8 1-(4-methoxyphenyl)-4-phenyl-1,4-butanedione 

Relevant articles and documents

Copper-Catalyzed Aerobic Oxidative Cleavage of Unstrained Carbon-Carbon Bonds of 1,1-Disubstituted Alkenes with Sulfonyl Hydrazides

Alkoxy radical-mediated carbon-carbon bond cleavages have emerged as a powerful strategy to complement traditional ionic-type transformations. However, carbon-carbon cleavage reaction triggered by alkoxy radical intermediate derived from the combination of alkyl radical and dioxygen, is scarce and underdeveloped. Herein, we report alkoxy radical, which was generated from alkyl radical and dioxygen, mediated selective cleavage of unstrained carbon-carbon bond for the oxysulfonylation of 1,1-disubstituted alkenes, providing facile access to a variety of valuable β-keto sulfones. Mechanistic experiments indicated alkoxy radical intermediate that underwent subsequent regioselective β-scission might be involved in the reaction and preliminary computational studies were conducted to provide a detailed explanation on the regioselectivity of the C—C bond cleavage. Notably, the strategy was successfully applied for constructing uneasily obtained architecturally intriguing molecules.

Aerobic Oxidative Dehydrogenation of Ketones to 1,4-Enediones

An efficient and unprecedented strategy for the synthesis of 1,4-enediones from saturated ketones has been developed via palladium-catalyzed oxidative dehydrogenation. The protocol employs molecular oxygen as the sole oxidant and represents an atom- and step-economic process. The approach showed broad substrate scope, good functional group tolerance, and complete E-stereoselectivity. The reaction mechanism has been investigated through deuterium-labeling experiments and intermediate experiments.

Synthesis of (E)-1,4-diaryl-2-butene-1,4-diones

We report a facile route for the preparation of symmetric and unsymmetric (E)-1,4-diaryl-2-butene-1,4-diones 3 by a two-step route, including (1) nucleophilic substitution of 1 with sulfinic acid sodium salts, and (2) K2CO3 mediated alkylation of β-ketosulfones 4 with 1 followed by sequential desulfonylation of the resulting 1,4-diketones 5 in acetone. These products were obtained in high yields.