128318-85-4

Upstream product

• 591-50-4 iodobenzene 
• 463-49-0 1,2-propanediene 
• 6006-81-1 3-hydroxy-2-phenylpropene 
• 5155-87-3 3-phenylbut-3-enoic acid 
• 98-83-9 isopropenylbenzene 
• 36043-44-4 (1,2-dibromopropan-2-yl)benzene 
• 3360-54-1 3-bromo-2-phenylprop-1-ene 
• 108-86-1 bromobenzene 
• 4648-54-8 trimethylsilylazide 
• 86537-63-5 Ethyl 2-Phenyl-2-propenyl carbonate 

Downstream Products

• 1447974-69-7 5-(chloromethyl)-5-phenyloxazolidin-2-one 
• 1447974-60-8 5-(chloromethyl)-5-phenyloxazolidin-2-one 
• 28144-67-4 2-phenylallylamine 
• 256950-59-1 N-[2-(phenyl)prop-2-en-1-yl]-N-tert-butoxycarbonyl amide 
• 23128-65-6 2-bromo-1-phenyl-2-(toluene-4-sulfonyl)ethanone 
• 71899-75-7 2-hydroxy-2-phenylethyl 4-methylphenyl sulfone 
• 1104732-64-0 (E)-1,5-diphenyl-2-tosylpent-4-en-1-one 
• 40240-72-0 (E)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4- dione 
• 31378-03-7 1-phenyl-2-tosylethanone 

Relevant academic research and scientific papers

One-pot sequential and cascade formation of triazoles via palladium catalysed azide capture-1,3-dipolar cycloaddition

The development of cascade and sequential processes comprising the formation of allylic azides, from aryl/heteroaryl/vinyl halides, allene and sodium azide, by palladium catalysed anion capture, and cyclisation-anion capture, followed by 1,3-dipolar cycloaddition gives rise to a variety of new triazoles in good yield.

PALLADIUM(0)-CATALYZED AZIDATION OF ALLYL ESTERS WITH TRIMETHYLSILYL AZIDE

Palladium(0)-catalyzed reaction of allyl esters with trimethylsilyl azide gives, under anhydrous conditions, the corresponding allyl azides.

Highly selective hydrosilylation of equilibrating allylic azides

The Pt-catalyzed hydrosilylation of equilibrating allylic azides is reported. The reaction provides only one out of four possible hydrosilylation products in good yields and with very high chemoselectivity (alk-1-enevs.alk-2-ene), regioselectivity (linearvs.branched), and excellent functional group tolerance.

Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes

A versatile method for the rapid synthesis of diverse enantiomerically enriched lactones has been developed based on Cu-catalyzed enantioselective radical oxyfunctionalization of alkenes. The scope of this strategy encompasses a series of enantioselective difunctionalization reactions: oxyazidation, oxysulfonylation, oxyarylation, diacyloxylation, and oxyalkylation. These reactions provide straightforward access to a wide range of useful chiral lactone building blocks containing tetrasubstituted stereogenic centers, which are hard to access traditionally. (Chemical Equation Presented).

Synthesis method of 3-azidopropylsilane

The invention discloses a synthetic method of 3-azidopropylsilane, wherein the method comprises the steps: firstly, allyl azide is synthesized by allyl bromide, and because the allyl azide is easy togenerate [3,3] rearrangement reaction at room temperatur

Practical regio- and stereoselective azidation and amination of terminal alkenes

There is significant interest in developing more rapid and efficient production of nitrogen-containing allylic compounds, as widely used in various syntheses. This work reports a variety of allylic azides and allylic amines synthesized by an efficient, new one-pot protocol that employs readily available terminal alkenes as starting materials. This method is highly regio- and stereoselective, affording the linear (E)-isomer, under metal-free conditions. This process tolerates several functional groups including halogen-containing molecules; it is general for azides and amine nucleophiles; and, adducts were obtained in good yields.

Solvent-dependent enantiodivergence in the chlorocyclization of unsaturated carbamates

A remarkable solvent-controlled enantiodivergence is seen in the hydroquinidine 1,4-phthalazinediyl diether ((DHQD)2PHAL)-catalyzed chlorocyclization of unsaturated carbamates. Eyring plot analyses of this previously unreported reaction are used to probe and compare the R- and S-selective pathways. In the CHCl3/hexanes solvent system, the pro-R process shows a surprising increase in selectivity with increasing temperature. These studies point to a strongly solvent-dependent entropy-enthalpy balance between the pro-R and pro-S pathways. Two solvents, two enantiomers: Enantiodivergent hydroquinidine 1,4-phthalazinediyl diether ((DHQD) 2PHAL)-catalyzed chlorocyclization of unsaturated carbamates, controlled solely by the choice of solvent, yields oxazolidinones in high enantioselectivity (see scheme; DCDMH=1,3-dichloro-5,5-dimethyl hydantoin). The origin of the observed enantiodivergence is traced back to a solvent-selected entropy-enthalpy balance between pro-R and pro-S pathways that dictates the course of the reaction. Copyright