40240-73-1

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 99-90-1 para-bromoacetophenone 
• 1777-57-7 p-bromobenzoylmethylenetriphenylphosphorane 
• 17282-37-0 1-(p-bromophenacyl)pyridinium bromide 
• 70-11-1 α-bromoacetophenone 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 101028-23-3 trans-1-(p-bromophenyl)-2,3-epoxy-4-phenylbutane-1,4-dione 
• 101028-23-3 cis-1-(p-bromophenyl)-2,3-epoxy-4-phenylbutane-1,4-dione 
• 22867-13-6 2,3-dibromo-1-(4-bromo-phenyl)-4-phenyl-butane-1,4-dione 
• 22862-57-3 cis-1-(p-bromophenyl)-4-phenyl-2-butene-1,4-dione 

Relevant academic research and scientific papers

Aerobic Oxidative Dehydrogenation of Ketones to 1,4-Enediones

An efficient and unprecedented strategy for the synthesis of 1,4-enediones from saturated ketones has been developed via palladium-catalyzed oxidative dehydrogenation. The protocol employs molecular oxygen as the sole oxidant and represents an atom- and step-economic process. The approach showed broad substrate scope, good functional group tolerance, and complete E-stereoselectivity. The reaction mechanism has been investigated through deuterium-labeling experiments and intermediate experiments.

Synthesis of (E)-1,4-enediones from α-halo ketones through a sodium sulfinate mediated reaction

We developed a mild and practical protocol for the synthesis of 1,4-enedione from α-halo ketones through a sodium sulfinate mediated reaction. This reaction enables the construction of symmetric and unsymmetric 1,4-enedione with complete E selectivity. Sodium 4-toluenesulfinate plays an important role in this reaction.

Stereospecific Epoxidation of cis-2-Butene-1,4-diones to cis-2,3-Epoxybutane-1,4-diones with Oxodiperoxomolybdenum (VI), MoO5*H2O*HMPA

The epoxidation of cis-2-butene-1,4-diones 4 with (aqua)(hexamethylphosphoramide)oxodiperoxomolybdenum (VI), MoO5*H2O*HMPA, occured stereospecifically to give the cis-epoxides 5, whose stereochemistry was assigned on the basis of chemical evidence and a comparision of their spectral data with those of the corresponding trans-epoxides 6, which were prepared by the epoxidation of the trans-olefins 3 with alkaline hydrogen peroxide.