40277-63-2

Basic information

• Product Name: 4-methoxy-N'-phenylbenzohydrazonoyl chloride
• Synonyms: 4-methoxy-N'-phenylbenzohydrazonoyl chloride
• CAS NO: 40277-63-2
• Molecular Weight: 260.723
• Mol File: 40277-63-2.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 4-methoxy-N'-phenylbenzohydrazonoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N'-phenylbenzohydrazonoyl chloride(40277-63-2)
• EPA Substance Registry System: 4-methoxy-N'-phenylbenzohydrazonoyl chloride(40277-63-2)

Safety Data

• Hazardous Substances Data: 40277-63-2(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 15089-03-9 4-methoxy-N'-phenylbenzohydrazide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 622-73-1 4-methoxybenzaldehydephenylhydrazone 
• 622-73-1 (E)-1-(4-methoxybenzylidene)-2-phenylhydrazine 

Downstream Products

• 40277-67-6 3-(4-methoxy-phenyl)-1-phenyl-(3ar,8bc)-3a,8b-dihydro-1H-benzo[4,5]furo[3,2-c]pyrazole 
• 142397-05-5 3-(4-Methoxy-phenyl)-1-phenyl-1,8a-dihydro-[1,2,4]triazolo[4,3-a]pyridine 
• 132703-69-6 N-[1-Imidazol-1-yl-1-(4-methoxy-phenyl)-meth-(E)-ylidene]-N'-phenyl-hydrazine 
• 142397-13-5 1-(4-Methoxy-phenyl)-3-phenyl-3,3a-dihydro-[1,2,4]triazolo[4,3-a]quinoline 
• 31023-85-5 dispirodithietane-4',2''-adamantane> 
• 95549-26-1 C₂₄H₂₆N₂OS 
• 118485-19-1 C₃₁H₂₆N₂O₂ 
• 118485-27-1 C₃₆H₂₈N₂O₂ 
• 118485-22-6 C₃₂H₂₈N₂O₂ 
• 143739-66-6 1-para-anisyl-7,8-dimethoxy-4-methyl-3-phenyl-3a,4,5,9b-tetrahydropyrazolo<3,4-c>isoquinoleine-3a-carboxylate d'ethyle 
• 143166-96-5 1-para-anisyl-7,8-dimethoxy-4,5-dimethyl-3-phenyl-3a,4,5,9b-tetrahydropyrazolo<3,4-c>isoquinoleine-3a-carboxylate d'ethyle 
• 118485-37-3 C₃₃H₃₀N₂O₂ 
• 118485-30-6 C₃₇H₃₀N₂O₂ 
• 93072-74-3 C-(4-methoxyphenyl)-N-phenylnitrile imine 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

1,3-dipolar cycloaddition reactions of the compound obtaining from cyclopentadiene-PTAD and biological activities of adducts formed selectively

After known adduct (4) was synthesized by cycloaddition reaction of cyclopentadiene with 4-phenyl-1,2,4-triazoline-3,5-dione, seven new isoxazoline derivatives were synthesized from reactions of 4 with corresponding oximes prepared from benzaldehyde derivatives in the existence of the aqueous NaOCl in CH2Cl2 at 0°C—RT via nitrile oxides. Four new pyrazoline derivatives were also synthesized from reactions of 4 with corresponding prepared reagents via nitrile imines. Selectively, each of all isoxazole and pyrazoline derivatives was synthesized by 1,3-dipolar cycloaddition reactions of compound 4 with the corresponding reagents. Based on the results of their biological activity analyses, Ki values for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glucosidase (α-Gly) enzymes were obtained in this range 32.15 ± 5.73–107.44 ± 19.52 22.57 ± 4.30–186.07 ± 23.51, and 69.08 ± 8.54–528.07 ± 38.46 nM, respectively. Besides that, these compounds were subjected to molecular docking to describe the interaction against AChE, BChE, and α-Gly enzymes in which important interactions were visualized and evaluated with residues of the binding region in each target enzyme.

A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles

N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is