40277-76-7

Basic information

• Product Name: METHYL B-(P-NITROPHENYL)METHACRYLATE
• Synonyms: METHYL B-(P-NITROPHENYL)METHACRYLATE
• CAS NO: 40277-76-7
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.21
• Mol File: 40277-76-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL B-(P-NITROPHENYL)METHACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL B-(P-NITROPHENYL)METHACRYLATE(40277-76-7)
• EPA Substance Registry System: METHYL B-(P-NITROPHENYL)METHACRYLATE(40277-76-7)

Safety Data

• Hazardous Substances Data: 40277-76-7(Hazardous Substances Data)

Upstream product

• 1199-77-5 α-methylcinnamic acid 
• 120-57-0 piperonal 
• 1367876-29-6 [(Z)-2-methoxycarbonyl-3-(4-nitrophenyl)-2-propenyl]triphenylphosphonium bromide 
• 80-62-6 methacrylic acid methyl ester 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 
• 100-01-6 4-nitro-aniline 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 555-16-8 4-nitrobenzaldehdye 
• 100-52-7 benzaldehyde 
• 21370-57-0 methyl 2-methyl-3-phenylacrylate 
• 2689-62-5 (1-methoxy-1-oxopropan-2-yl)triphenylphosphonium bromide 
• 58550-34-8 (E)-2-methyl-3-(4-nitrophenyl)acrylaldehyde 
• 67-56-1 methanol 

Downstream Products

• 494857-78-2 C₃₄H₃₅N₃O₄S 
• 494857-73-7 C₃₃H₃₄N₄O₄S 
• 494857-30-6 C₃₅H₃₆N₄O₄ 
• 494857-52-2 C₃₆H₃₈N₄O₄ 
• 494857-43-1 C₃₆H₃₈N₄O₄ 
• 494857-47-5 C₃₅H₃₇N₅O₄ 
• 494857-56-6 C₃₆H₃₈N₄O₄ 
• 494857-60-2 C₃₄H₃₅N₅O₄ 
• 37542-81-7 (2E)-2-methyl-3-(4-nitrophenyl)prop-2-en-1-ol 
• 13048-77-6 (E)-2-methyl-3-(4-nitrophenyl)acrylic acid 

Relevant articles and documents

Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthetic work on marine natural product Chrysamide B, it and a series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure–activity relationships were conducted. Among them, Chrysamide B is the most potent anti-inflammatory agent with low cytotoxicity and strong inhibition on the production of NO (IC50 = 0.010 μM) and the activity of iNOS (IC50 = 0.082 μM) in LPS-stimulated RAW 264.7 cells. Primary studies suggested that the mechanism of action may be that it interfered the formation of active dimeric iNOS but not affected transcription and translation. Furthermore, its good performance of anti-inflammatory effect on LPS-induced multiple inflammatory cytokines production, carrageenan-induced paw edema, and endotoxin-induced septic mice, was observed. We believe that these findings would provide an idea for the further modification and research of these analogs in the future.

Novel piperazine compound as well as preparation method and application thereof

The structural general formula of a novel piperazine compound is shown in the specification. The invention aims to provide a novel anti-inflammatory drug with high efficiency and low side effect. Because typical marine characteristic skeleton molecules ri

Palladium(II) supported on polycarbosilane: Application as reusable catalyst for Heck reaction

Heck reaction catalyzed by palladium(II) attached polycarbosilane is reported. Polycarbosilane (PCS), which is an organic-inorganic hybrid polymer containing both Si and C in its back bone structure, was synthesized by the polycondensation of trichloromethylsilane and trimethoxyvinylsilane in the presence of sodium metal. Palladium acetate was attached to the polycarbosilane (Pd-PCS) and its catalytic activity was investigated. Heck reaction in which C-C coupling between aryl halides or vinyl halides and activated alkenes in the presence of a base has been selected for the study. Palladium ions supported on PCS have been used as a catalyst for the first time and it efficiently catalyzed Heck reaction and an yield of 75-90% was obtained with different substrates. For comparison, catalytic activities of Pd ions supported on SBA-15, activated charcoal and amorphous silica were also investigated. Results indicate the superior activity of Pd-PCS.