40290-65-1

Basic information

• Product Name: L-Methionine, N-L-phenylalanyl-, methyl ester, monohydrochloride
• CAS NO: 40290-65-1
• Molecular Formula: C15H22N2O3S.ClH
• Molecular Weight: 346.878
• Mol File: 40290-65-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: L-Methionine, N-L-phenylalanyl-, methyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Methionine, N-L-phenylalanyl-, methyl ester, monohydrochloride(40290-65-1)
• EPA Substance Registry System: L-Methionine, N-L-phenylalanyl-, methyl ester, monohydrochloride(40290-65-1)

Safety Data

• Hazardous Substances Data: 40290-65-1(Hazardous Substances Data)

Upstream product

• 2491-18-1 (S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride 
• 4192-12-5 Boc-Phe-OH*DCHA 
• 16118-36-8 methionine methyl ester hydrochloride 
• 26061-07-4 Boc-Phe-Met-OMe 
• 63-68-3 L-methionine 
• 10332-17-9 Met-OMe 
• 81638-94-0 O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 40290-63-9 Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine 

Downstream Products

• 58569-54-3 tert-Butoxycarbonyl-o-benzyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester 
• 63631-34-5 tert-Butyloxycarbonyl-O-benzyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionin 
• 88223-91-0 N-<(1R,S)-2-(4-Benzyloxyphenyl)-1-carboxyethylaminocarbonyl>glycyl-glycyl-DL-phenylalanyl-DL-methionin 
• 88223-93-2 O-Benzyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionin-hydrochlorid 
• 88223-92-1 O-Benzyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester-hydrochlorid 
• 70035-45-9 N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester 
• 1228804-21-4 [3-(Fmoc-glycylamino)-2-methylenepropanoyl]-L-phenylalaninyl-L-methionine methyl ester 
• 80727-54-4 Boc-Gly-Phe-Met-Tyr-Gly-N₂H₃ 
• 80727-52-2 Boc-Gly-Phe-Met-Tyr-Gly-OMe 
• 80727-49-7 cyclo-Met⁵-Enkephalin 
• 80727-51-1 Boc-Gly-Phe-Met-N₂H₃ 
• 81649-52-7 methyl ester of N,O-di-t-butyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine 
• 70035-46-0 hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine 
• 58569-55-4 met-enkephalin 

Relevant articles and documents

Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis

Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very important, but it typically relies on a multistep procedure. We here report a dynamic kinetic cross-coupling approach for the direct functionalization of alcohols. The feasibility of this strategy is demonstrated by a nickel-catalyzed cross-electrophile arylation reaction of benzyl alcohols with (hetero)aryl electrophiles. The reaction proceeds with a broad substrate scope of both coupling partners. The electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles (e.g., Ar-OTf, Ar-I, Ar-Br, and inert Ar-Cl) all coupled well. Most of the functionalities, including aldehyde, ketone, amide, ester, nitrile, sulfone, furan, thiophene, benzothiophene, pyridine, quinolone, Ar-SiMe3, Ar-Bpin, and Ar-SnBu3, were tolerated. The dynamic nature of this method enables the direct arylation of benzylic alcohol in the presence of various nucleophilic groups, including nonactivated primary/secondary/tertiary alcohols, phenols, and free indoles. It thus offers a robust alternative to existing methods for the precise construction of diarylmethanes. The synthetic utility of the method was demonstrated by a concise synthesis of biologically active molecules and by its application to peptide modification and conjugation. Preliminary mechanistic studies revealed that the reaction of in situ formed benzyl oxalates with nickel, possibly via a radical process, is an initial step in the reaction with aryl electrophiles.

Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme

The effectiveness of phosphonamidate peptide analogues as inhibitors of rat kidney or human brain metallo-endopeptidase (enkephalinase, E.C. 3.4.24.11) and angiotensin-converting enzyme (ACE, 3.4.15.1) has been explored with a series of enkephalin analogu

O-(N-ACYLAMINOACYL)-2-PYRIDYLMETHYLKETOXIMES AND THEIR USE IN PEPTIDE SYNTHESIS

Preparation of Leu-enkephalin, Met-enkephalin and one analog of Leu-enkephalin by using O-(N-acylaminoacyl)-2-pyridylketoximes is described.Both the side products and the unreacted active amino acid derivatives were removed by utilizing the formation of a copper complex with 2-pyridylmethylketoxime.