62530-43-2

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 40290-63-9 Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine 
• 40290-65-1 hydrochloride of methyl ester of L-phenylalanyl-L-methionine 
• 78553-40-9 glycylphenylalanylmethionine methyl ester hydrochloride 
• 70035-46-0 hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine 
• 70035-45-9 N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester 
• 69872-63-5 N-(tert-butyloxycarbonyl)glycyl-L-phenylalanyl-L-methionine methyl ester 
• 71921-21-6 Boc-Tyr(But)-Gly-Gly-Phe-OMe 
• 71921-22-7 Boc-Tyr(But)-Gly-Gly-Phe-OH 
• 47375-34-8 Boc-Tyr(t-Bu)-OH 
• 61131-29-1 N-glycyl>-L-3-phenylalanine methyl ester hydrochloride 
• 71921-23-8 Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met-OMe 

Downstream Products

• 59481-78-6 H-Tyr-Gly-Gly-Phe-Met-OH 
• 58569-55-4 met-enkephalin 

Relevant academic research and scientific papers

A Convenient Synthesis of Met-enkephalin Using 1-β-Naphthalenesulphonyloxybenzotriazole for Peptide Bond Formation

A convenient procedure for the synthesis of Met-enkephalin involving the use of 1-β-naphthalenesulphonyloxybenzotriazole as the peptide coupling reagent is described.Boc group is employed for the protection of α-NH2 functions of amino acids and its cleavage from the intermediate peptides is brought about by HCOOH in the presence of C6H5-OCH3 and SH-(CH2)2-SH without the formation of side products.The resulting formates are converted to the corresponding hydrochlorides prior to their coupling with the carboxy component.All the intermediate peptides have been obtained in high yields.