676560-01-3

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-diMethylethyl ester
• Synonyms: 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-diMethylethyl ester;tert-Butyl 6-fluoronicotinate;2-Fluoroisonicotinic acid tert-butyl ester;6-Fluoronicotinic acid tert-butyl ester
• CAS NO: 676560-01-3
• Molecular Formula: C₁₀H₁₂FNO₂
• Molecular Weight: 197.2061832
• Mol File: 676560-01-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-diMethylethyl ester(676560-01-3)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-diMethylethyl ester(676560-01-3)

Safety Data

• Hazardous Substances Data: 676560-01-3(Hazardous Substances Data)

Usage

General Description

3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-dimethylethyl ester is a chemical compound that falls under the category of esters. It is derived from the carboxylic acid 3-pyridinecarboxylic acid and contains a fluorine atom at the 6th position of the pyridine ring. The esterification of this compound with 1,1-dimethylethanol results in the formation of the 1,1-dimethylethyl ester. This chemical is commonly used in organic synthesis and pharmaceutical industries as a key building block for the production of various drugs and pharmaceutical intermediates. Additionally, the fluoro substitution on the pyridine ring provides unique properties and can potentially be used to modify the biological activity of target molecules.

Upstream product

• 65321-36-0 t-butyl nicotinate 
• 403-45-2 6-fluoronicotinic acid 
• 75-65-0 tert-butyl alcohol 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 

Downstream Products

• 813433-93-1 6-(4-amino-4-methyl-cyclohexyloxy)-N,N-dimethyl-nicotinamide 

Relevant articles and documents

Selective C-H fluorination of pyridines and diazines inspired by a classic amination reaction

Fluorinated heterocycles are prevalent in pharmaceuticals, agrochemicals, and materials. However, reactions that incorporate fluorine into heteroarenes are limited in scope and can be hazardous. We present a broadly applicable and safe method for the site-selective fluorination of a single carbon-hydrogen bond in pyridines and diazines using commercially available silver(II) fluoride. The reactions occur at ambient temperature within 1 hour with exclusive selectivity for fluorination adjacent to nitrogen. The mild conditions allow access to fluorinated derivatives of medicinally important compounds, as well as a range of 2-substituted pyridines prepared by subsequent nucleophilic displacement of fluoride. Mechanistic studies demonstrate that the pathway of a classic pyridine amination can be adapted for selective fluorination of a broad range of nitrogen heterocycles.

Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)

The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclero

PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)

The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.