4033-46-9Relevant articles and documents
Optical Resolution by Preferential Crystallization of (RS)-2-Amino-3-(2-carboxyethylthio)propanoic Acid
Shiraiwa, Tadashi,Kubo, Motoki,Watanabe, Mitsuhiro,Nakatani, Hidemasa,Ohkubo, Masanori,Kurokawa, Hidemoto
, p. 818 - 820 (2007/10/03)
Electrophilic additions of DL- and L-Cys to propenoic acid afforded (RS)- and (R)-2-amino-3-(2-carboxyethylthio)propanoic acids , respectively. (RS)-ACE was found to exist as a conglomerate based on its melting point, solubility, and infrared spectrum. (RS)-ACE was optically resolved by preferential crystallization to yield (R)- and (S)-ACE.The obtained (R)- and (S)-ACE were efficiently recrystallized from water, taking account of the solubility of (RS)-ACE, to give them in optically pure form. - Keywords: optically active 2-amino-3-(2-carboxyethylthio)propanoic acid; conglomerate; optical resolution; preferential crystallization