40348-72-9

Basic information

• Product Name: methyl 2-hydroxy-4-methylvalerate
• Synonyms: methyl 2-hydroxy-4-methylvalerate;Pentanoic acid, 2-hydroxy-4-methyl-, methyl ester;METHYL-2-HYDROXY-4-METHYLPENTANOATE;2-Hydroxy-4-methylpentanoic acid methyl ester;4-Methyl-2-hydroxypentanoic acid methyl ester;Methyl DL-2-Hydroxy-4-Methylvalerate
• CAS NO: 40348-72-9
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.18426
• EINECS: 254-883-4
• Mol File: 40348-72-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 181.6 °C at 760 mmHg
• Flash Point: 65.6 °C
• Appearance: Colourless liquid with sweet, fruity, musty odour
• Density: 1.002 g/cm³
• Vapor Pressure: 0.247mmHg at 25°C
• Refractive Index: 1.43
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 13.07±0.20(Predicted)
• CAS DataBase Reference: methyl 2-hydroxy-4-methylvalerate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-hydroxy-4-methylvalerate(40348-72-9)
• EPA Substance Registry System: methyl 2-hydroxy-4-methylvalerate(40348-72-9)

Safety Data

• Hazardous Substances Data: 40348-72-9(Hazardous Substances Data)

Usage

Description

Methyl 2-hydroxy-4-methylpentanoate has a sweet, fruity, musty odor.

Chemical Properties

Methyl 2-hydroxy-4-methylpentanoate has a sweet, fruity, musty odor

Occurrence

Reported found in guanabana

InChI:InChI=1/C7H14O3/c1-5(2)4-6(8)7(9)10-3/h5-6,8H,4H2,1-3H3

Upstream product

• 95205-13-3 methyl 2-diazo-4-methylpentanoate 
• 89426-79-9 (1S,2S,6R,7R)-4-(1-Methoxymethoxy-3-methyl-butyl)-1,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-ene 
• 922-68-9 Methyl glyoxylate 
• 115-11-7 isobutene 
• 186581-53-3 diazomethane 
• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 67-56-1 methanol 
• 141-46-8 Glycolaldehyde 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 6087-17-8 2-fluoro-4-methylpentanoic acid 
• 108061-34-3 methyl L-2-(benzyloxy)-4-methylpentanoate 
• 108061-23-0 L-2-(benzyloxy)-4-methylpentanoic acid 
• 108061-24-1 methyl (L-2-(benzyloxy)-4-methylpentanoyl)-L-alaninate 
• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 76905-01-6 4-Methyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid methyl ester 
• 112529-90-5 (R)-methyl 2-hydroxy-4-methylpentanoate 

Relevant articles and documents

PROCESS OF PRODUCING ALPHA-HYDROXY COMPOUNDS AND USES THEREOF

New process of producing alpha-hydroxy compounds from sustainable resources useful as platform chemicals, such as hydroxy analogues of amino acids or polymer precursors.

Catalytic asymmetric glyoxylate-ene reaction: A practical access to α-hydroxy esters in high enantiomeric purities

An efficient asymmetric catalysis is developed for the glyoxylate-ene reaction to afford the α-hydroxy esters of biological and synthetic importance. The key to the success is the use of the chiral titanium complex prepared in situ from (i-PrO)2TiX2 (X = Cl or Br) and the (R)- or (S)-binaphthol in the presence of molecular sieves (MS 4A). The presence of the molecular sieves (zeolite) is clarified to facilitate the alkoxy-ligand exchange reaction. Thus, the use of MS is shown to be essential for the in situ preparation step of the chiral catalyst and not for the ene reaction step. The present catalytic process is applicable to various 1,1-disubstituted olefins by the judicious choice of the dichloro or dibromo catalyst.