342043-42-9

Basic information

• Product Name: 1-nitro-5,6,7,8-tetrahydro-2-naphthalenamine
• Synonyms: 1-nitro-5,6,7,8-tetrahydro-2-naphthalenamine
• CAS NO: 342043-42-9
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.21448
• Mol File: 342043-42-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-nitro-5,6,7,8-tetrahydro-2-naphthalenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitro-5,6,7,8-tetrahydro-2-naphthalenamine(342043-42-9)
• EPA Substance Registry System: 1-nitro-5,6,7,8-tetrahydro-2-naphthalenamine(342043-42-9)

Safety Data

• Hazardous Substances Data: 342043-42-9(Hazardous Substances Data)

Usage

General Description

1-nitro-5,6,7,8-tetrahydro-2-naphthalenamine, also known as 1-nitro-THN, is an organic compound with the molecular formula C10H11NO2. It is a nitro derivative of tetrahydro-2-naphthylamine and is used in the research of potential drugs for the treatment of Parkinson's disease. 1-nitro-5,6,7,8-tetrahydro-2-naphthalenamine has been shown to exhibit neuroprotective effects and is being studied for its potential as a therapeutic agent for neurological disorders. Additionally, 1-nitro-THN has demonstrated anti-inflammatory and antioxidant properties, making it a promising candidate for further investigation in the field of medicinal chemistry and drug development. However, its toxicological and pharmacological profiles are still being researched and evaluated for potential therapeutic applications.

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 40353-34-2 7-nitro-3,4-dihydro-2H-naphthalen-1-one 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 
• 19353-86-7 6-nitrotetralin 
• 90-15-3 α-naphthol 
• 119-64-2 tetralin 
• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 64-17-5 ethanol 
• 103041-08-3 5,6-dinitro-1,2,3,4-tetrahydro-naphthalene 
• 104509-00-4 N-(1-nitro-5,6,7,8-tetrahydro-2-naphthalenyl)acetamide 

Downstream Products

• 103639-82-3 N₂-methyl-5,6,7,8-tetrahydronaphthalene-1,2-diamine 
• 1384868-13-6 N-methyl-1-nitro-5,6,7,8-tetrahydronaphthalen-2-amine 
• 1339147-87-3 C₂₀H₁₇N₃ 
• 130728-37-9 N-(1-nitro-5,6,7,8-tetrahydro-[2]naphthyl)-toluene-4-sulfonamide 
• 40300-80-9 5,6-diamino-1,2,3,4-tetrahydronaphthalene 
• 6240-80-8 1-nitro-5,6,7,8-tetrahydronaphthalen-2-ol 

Relevant articles and documents

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

A series of novel tricyclic triazine-di-N-oxides (TTOs) related to tirapazamine have been designed and prepared. A wide range of structural arrangements with cycloalkyl, oxygen-, and nitrogen-containing saturated rings fused to the triazine core, coupled with various side chains linked to either hemisphere, resulted in TTO analogues that displayed hypoxia-selective cytotoxicity in vitro. Optimal rates of hypoxic metabolism and tissue diffusion coefficients were achieved with fused cycloalkyl rings in combination with both the 3-aminoalkyl or 3-alkyl substituents linked to weakly basic soluble amines. The selection was further refined using pharmacokinetic/pharmacodynamic model predictions of the in vivo hypoxic potency (AUCreq) and selectivity (HCD) with 12 TTO analogues predicted to be active in vivo, subject to the achievement of adequate plasma pharmacokinetics.