40371-61-7

Basic information

• Product Name: N-(3-Bromo-4-methylphenyl)acetamide
• Synonyms: 3'-Bromo-4'-methylacetanilide;N-(3-Bromo-4-methylphenyl)acetamide
• CAS NO: 40371-61-7
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 0
• Mol File: 40371-61-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-Bromo-4-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Bromo-4-methylphenyl)acetamide(40371-61-7)
• EPA Substance Registry System: N-(3-Bromo-4-methylphenyl)acetamide(40371-61-7)

Safety Data

• Hazardous Substances Data: 40371-61-7(Hazardous Substances Data)

Upstream product

• 7745-91-7 3-bromo-4-methylaniline 
• 108-24-7 acetic anhydride 
• 103-89-9 4-Methylacetanilide 
• 75-05-8 acetonitrile 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 507-09-5 tiolacetic acid 
• 10387-40-3 potassium thioacetate 

Downstream Products

• 101251-11-0 3-bromo-N,4-dimethylbenzenamine 
• 40371-62-8 acetic acid-(5-bromo-4-methyl-2-nitro-anilide) 
• 13480-37-0 3-phenyl-4-methylaniline 
• 872856-30-9 ethyl 2-(5-acetylamino-2-methylphenyl)-2-oxoacetate 
• 1374606-94-6 C₁₀H₉BrF₃NO 
• 1374606-60-6 N-(5-bromo-4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 1338684-18-6 5-(4-methoxybutyl)-4-methyl-N-(3-phenylpropyl)benzene-1,2-diamine 
• 1338684-21-1 5-[(2E)-4-methoxybut-2-en-1-yl]-4-methyl-2-nitro-N-(3-phenylpropyl)aniline 
• 1338684-20-0 5-allyl-4-methyl-2-nitro-N-(3-phenylpropyl)aniline 
• 1338684-19-7 5-bromo-4-methyl-2-nitro-N-(3-phenylpropyl)aniline 
• 1172115-34-2 C₁₅H₂₂BNO₃ 
• 2486-52-4 2-bromo-4-aminobenzoic acid 
• 70733-25-4 3-Bromo-5-methyl-1,2-diaminobenzene 
• 62827-39-8 3-Bromo-5-nitro-p-toluidine 

Relevant articles and documents

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

Synthesis of acetamides from aryl amines and acetonitrile by diazotization under metal-free conditions

An efficient and metal-free coupling reaction has been developed that affords acetamides from the corresponding aryl amines and acetonitrile. This method tolerates a wide range of functional groups and is selective toward aryl amines. Preliminary mechanistic studies were conducted.

One-step reductive amidation of nitro arenes: Application in the synthesis of Acetaminophen

A novel thioacetate mediated one-step reductive acetamidation of aryl nitro compounds was developed and applied to an efficient synthesis of acetaminophen. The reaction also proceeds well without a solvent in the presence of a catalytic amount of surfactant.

ONE-POT REDUCTIVE ACETAMIDATION OF ARYL NITRO COMPOUNDS

The present invention provides a method for the reductive acetamidation of an aryl nitro compound by reacting a substituted acid with an aryl nitro compound and adding a catalytic amount of a base with the substituted acid and the aryl nitro compound to form an acetamidation aryl nitro compound. The acetamidation aryl nitro compound is then purified.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly di

Eco-friendly reductive acetamidation of arylnitro compounds by thioacetate anion through in situ catalytic regeneration: application in the synthesis of Acetaminophen

A novel one-step reductive acetamidation of arylnitro compounds mediated by thioacetate anion in thioacetic acid via in situ catalytic regeneration was developed and applied to an efficient synthesis of Acetaminophen.

Pd-catalyzed ortho-selective oxidative coupling of halogenated acetanilides with acrylates

Coupling of different halogenated acetanilides with acrylates using Pd-catalyzed ortho-selective C-H bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron-rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions.

Molybdenum(VI)-catalysed Bromination. A Molybdenum Analogue Reaction Mimic for the Enzyme Bromoperoxidase

The molybdenum(VI)-catalysed bromination of organic substrates such as phenols and anilides with KBr in the presence H2O2 in an aqueous medium is reported.

Bromination Mediated by a Vanadium(V)-Peroxo Complex (GlyH = Glycine): a Functional Model for the Enzyme Bromoperoxidase

The reaction of potassium bromide with aromatic compounds C6H4XY (X=NHCOMe, Y=H or 4-Me; X=CHO, Y=2-OH) and 5,5-dimethylcyclohexa-1,3-dione in aqueous media in the presence of produces the corresponding brominated compounds; the reaction is proposed to be a mimic for the enzyme bromoperoxidase.

Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Part XXXIX - Reaction of 2-Mercapto-4-bromo-6-methylbenzimidazole with Chloroacetic Acid and 1,2-Dibromoethane

8-Bromo-6-methylthiazolobenzimidazol-3(2H)-one (IVa) and 8-bromo-6-methyl-2,3-dihydrothiazolobenzimidazole (V) have been synthesized starting from 2-mercapto-4-bromo-6-methylbenzimidazole (II), prepared by the reaction of 3-bromo-5-methyl-1,