457631-44-6

Usage

Uses

Used in Pharmaceutical Research and Development:
[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER is used as a building block for the synthesis of biologically active molecules due to its amine group, which can be utilized in the creation of various pharmaceutical compounds.
Used in Materials and Polymer Chemistry:
[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER is used as a component in the development of new materials and polymers, leveraging the potential of its phenyl group to contribute to the properties of these materials.

Upstream product

• 13472-00-9 p-Aminophenethylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40377-41-1 4-(2-(((methyl)carbonyl)amino)ethyl)aniline 
• 193204-58-9 tert-butyl N-(4-{2-[(4-methylbenzenesulfonyl)oxy]ethyl}phenyl)carbamate 
• 104060-23-3 tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 3544-25-0 p-aminophenylacetonitrile 
• 140-29-4 phenylacetonitrile 
• 555-21-5 4-Nitrophenylacetonitrile 
• 1233249-35-8 4-tert-butoxycarbonylaminophenylacetonitrile 

Downstream Products

• 457631-46-8 {4-[2-(5-[1,2]dithiolan-3-yl-pentanoylamino)-ethyl]-phenyl}-carbamic acid tert-butyl ester 
• 223673-61-8 (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide 
• 13472-00-9 p-Aminophenethylamine 
• 1608095-23-3 (1-{[2-(4-tert-butoxycarbonylaminophenyl)-ethylcarbamoyl]-methyl}-cyclopentyl)-acetic acid 
• 1608095-24-4 (1-{[2-(4-amino-phenyl)-ethylcarbamoyl]-methyl}-cyclopentyl)-acetic acid hydrochloride salt 
• 1608095-25-5 2-(1-(2-(4-(((9H-fluoren-9-yl)methoxy)carbonylamino)phenethylamino)-2-oxoethyl)cyclopentyl)acetic acid 
• 457631-50-4 5-[1,2]dithiolan-3-yl-pentanoic acid [2-(4-amino-phenyl)ethyl]amide 
• 457631-52-6 N-[2-(4-amino-phenyl)-ethyl]-2-[1,2]dithiolan-3-yl-acetamide 
• 457631-48-0 {4-[2-(2-[1,2]dithiolan-3-yl-acetylamino)-ethyl]-phenyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

METHOD FOR CLEAVING AMIDE BONDS

A method for cleaving amide bonds, comprising: a) providing a molecule comprising an amide group;b) reacting the molecule comprising an amide group with hydroxylamine (NH2OH) or a salt thereof to cleave the amide bond of the amide group.

Rapid and Selective Cleavage of Amide Groups at Neutral pH: Applications from Hyaluronic Acid to Small Molecules

During our investigation to find suitable conditions to prepare very high molecular weight partially de-acetylated hyaluronic acid (HA), we discovered a powerful new method to cleave amide bonds using hydroxylamine salts at neutral pH with remarkable sele

A method of preparing P ethylamine

The invention discloses a preparation method of p-aminophenylethylamine, belonging to the technical field of organic synthesis. The technical scheme is as follows: the preparation method comprises the following steps: by using p-nitrophenylethanol as a raw material, carrying out catalytic hydrogenation to reduce the para-position nitro groups of the p-nitrophenylethanol into amino groups, carrying out Boc acid anhydride protection on the para-position nitro groups, carrying out substitution reaction on hydroxy groups with sulfonyl chloride compounds to obtain sulfonic acid compounds, aminating, and finally, removing Boc groups to obtain the p-aminophenylethylamine. The preparation process is simple and easy to implement, and has the advantages of cheap and accessible raw materials, higher reaction efficiency and favorable repetitiveness.

NOVEL PROCESS FOR PREPARATION OF MIRABEGRON AND IT'S INTERMEDIATE

The present invention related to a novel process for preparation of Mirabegron of formula (I) and its intermediate. I

Dynamic Covalent Assembly of Peptoid-Based Ladder Oligomers by Vernier Templating

Dynamic covalent chemistry, in conjunction with template-directed assembly, enables the fabrication of extended nanostructures that are both precise and tough. Here we demonstrate the dynamic covalent assembly of peptoid-based molecular ladders with up to 12 rungs via scandium(III)-catalyzed imine metathesis by employing the principle of Vernier templating, where small precursor units with mismatched numbers of complementary functional groups are coreacted to yield larger structures with sizes determined by the respective precursor functionalities. Owing to their monomer diversity and synthetic accessibility, sequence-specific oligopeptoids bearing dynamic covalent pendant groups were employed as precursors for molecular ladder fabrication. The generated structures were characterized using matrix-assisted laser desorption/ionization mass spectrometry and gel permeation chromatography, confirming successful molecular ladder fabrication.

COMPOUNDS FOR MODULATING IL-17

The invention relates generally to compounds and their therapeutic use. More particularly, the invention relates to compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.

Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection

Primary amines can be readily doubly protected as N-substituted 2,5-dimethylpyrroles. Although this protecting group is stable toward strong bases and nucleophiles, long reaction times are required for both the protection and deprotection steps, generally resulting in low deprotection yields. By employing microwave irradiation, protection and deprotection reaction times are dramatically reduced. Furthermore, deprotection with dilute hydrochloric acid in ethanol increases reaction yields. Diverse deprotection conditions have been developed in conjunction with microwave irradiation, so that protection as an N-substituted 2,5-dimethylpyrrole can be orthogonal to other standard amine protecting groups, such as tert-butyloxycarbonyl (Boc), carbobenzyloxy (Cbz), and 9-fluorenylmethyloxycarbonyl (Fmoc).

A method for the selective protection of aromatic amines in the presence of aliphatic amines

A simple and efficient procedure has been developed for the regioselective protection of aromatic amines in the presence of aliphatic amines. The method is general for the preparation of mono-N-Boc, -N-Cbz, -N-Fmoc or -N-Alloc aromatic amines in high yield without affecting the aliphatic amines. This approach is applicable to substituted (aminoalkyl)aniline compounds with different functionalities and was employed to supply gram quantities of the protected aniline product. Georg Thieme Verlag Stuttgart · New York.