40396-60-9

Basic information

• Product Name: Benzonitrile, 4-(1,1,2,2-tetrafluoro-2-phenylethyl)-
• CAS NO: 40396-60-9
• Molecular Formula: C15H9F4N
• Molecular Weight: 279.237
• Mol File: 40396-60-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(1,1,2,2-tetrafluoro-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(1,1,2,2-tetrafluoro-2-phenylethyl)-(40396-60-9)
• EPA Substance Registry System: Benzonitrile, 4-(1,1,2,2-tetrafluoro-2-phenylethyl)-(40396-60-9)

Safety Data

• Hazardous Substances Data: 40396-60-9(Hazardous Substances Data)

Upstream product

• 3058-39-7 4-iodobenzonitrile 
• 29822-79-5 4-(2-phenylethynyl)benzonitrile 
• 100-44-7 benzyl chloride 
• 2001-29-8 1-(4-bromophenyl)-2-phenyl-ethan-1-one 
• 623-00-7 4-bromobenzenecarbonitrile 
• 39229-12-4 4-bromobenzil 
• 40396-59-6 1-phenyl-2-p-bromophenyltetrafluoroethane 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 40396-63-2 4'-(α,α,β,β-tetrafluorophenethyl)-acetophenone 
• 40396-61-0 4-(α,α,β,β-tetrafluorophenethyl)-benzylamine 
• 40396-65-4 α-methyl-4-(2-phenyl-1,1,2,2-tetrafluoroethyl)benzylamine 

Relevant articles and documents

FLUORINE-CONTAINING COMPLEX COMPOUND, AND PRODUCTION METHOD FOR FLUORINE-CONTAINING ORGANIC COMPOUND EMPLOYING SAME

An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF2—CF2—). The present invention provides a flu

Direct addition of fluorine to arylacetylenes

Under suitable conditions elemental fluorine can be added across the carbon-carbon triple bond of arylacetylenes forming tetrafluoroethane derivatives - ArCF2CF2R - in good yields.

Tetrafluorophenethylaralkylamine compounds

New fluoro derivatives of aralkylamine compounds, particularly 2-(2-phenyl-1,1,2,2-tetrafluoroethyl)benzylamine, as well as the N-alkyl and the N,N-dialkyl derivatives thereof are prepared by reaction of 2-bromobenzonitrile with benzylmagnesium chloride to produce 2'-bromo-2-phenylacetophenone; oxidation of said acetophenone with selenous acid to produce 2-bromobenzil; conversion of the benzil compound by treatment with sulfur tetrafluoride to the corresponding 2-bromo-α ,α-α',α'-tetrafluorobibenzyl; followed by reaction of the 2-bromobibenzyl compound with a metal cyanide to produce the corresponding 2-(2-phenyl-1,1,2,2-tetrafluoroethyl)benzonitrile. This nitrile compound is then reduced with lithium aluminum hydride to produce the corresponding benzylamine, which is then converted, if desired, to the N-alkyl and/or N,N-dialkyl 2-(2-phenyl-1,1,2,2-tetrafluoroethyl)benzylamine. Alternatively, the nitrile or the precursor bromobibenzyl can be converted by Grignard reactions to the corresponding α-alkyl or α,α-dialkylbenzylamine which can then be converted if desired to the corresponding N-alkyl and/or N,N-dialkyl substituted benzylamine compound. The phenyltetrafluoroethylbenzylamine as well as its N-alkyl and N,N-dialkyl derivatives are active as antiarrhythmic agents.