404010-33-9

Upstream product

• 5396-38-3 1-(tert-butyl)-4-methoxybenzene 
• 77055-30-2 5-tert-butyl-2-methoxy-1,3-dinitrobenzene 
• 404010-31-7 5-tert-Butyl-2-methoxy-3-nitroaniline 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 404010-35-1 N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide 
• 1351997-22-2 (5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-carbamic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

Novel chromene diarylurea compounds, and preparation method and application thereof

The invention relates to compounds represented by the general formula I, or isomers, pharmaceutical salts and solvates thereof; the invention also relates to a composition containing the compounds represented by the general formula I, or the isomers, the

KINASE INHIBITOR

There is provided a compound of formula (I), which compound has antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases, e.g., Src and Lck) and has use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

KINASE INHIBITORS

There are provided compounds of formula I, wherein R1A to R1E, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

UREA DERIVATIVES USEFUL AS KINASE INHIBITORS

There are provided compounds of formula I, wherein R1A to R1E, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

Sulfonamide intermediates and methods of producing same

Disclosed are intermediates of the formula (A) and methods of making same. The intermediate compounds are useful in the synthesis of heteroaryl/aryl urea compounds,