404922-61-8

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 126-81-8 dimedone 
• 62-53-3 aniline 
• 589-18-4 4-Methylbenzyl alcohol 
• 351994-01-9 2,2'-((p-tolyl)methylene)bis(5,5-dimethylcyclohexane-1,3-dione) 
• 18940-21-1 5,5-dimethyl-3-(phenylamino)cyclohex-2-en-1-one 

Relevant academic research and scientific papers

Synthesis of 1,8-Dioxo-decahydroacridine Derivatives via Ru-Catalyzed Acceptorless Dehydrogenative Multicomponent Reaction

A Ru-catalyzed acceptorless dehydrogenative multicomponent reaction has been developed. This reaction offers a cost-effective and simple operational strategy to synthesize biologically active 1,8-dioxodecahydroacridine derivatives. The protocol provides a wide range of substrate scope and various functional groups are also well tolerated under the reaction condition. To shed light on the mechanistic and kinetic study, some controlled experiments and deuterium labeling experiments were executed. A time-dependent product distribution experiment is also presented and the reaction scale-up is performed to highlight the practical utility of this strategy.

Ferric (III) complex supported on superparamagnetic Fe3O4@SiO2 as a reusable Lewis acid catalyst: a new highly efficient protocol for the synthesis of acridinedione and spiroquinazolin-4(3H)-one derivatives

Nano-Fe3O4@SiO2-3,4-dihydroxybenzaldehyde/barbituric acid/phthalhydrazide-FeCl3 (nano-Fe3O4@SiO2-HBP-FeCl3) was prepared and authenticated by usual analytical and spectroscopic techniques. The prepared nano-Fe3O4@SiO2-HBP-FeCl3 was applied to acridinedione and spiroquinazolin-4(3H)-one derivatives under green conditions. In addition, this research offers several advantages such as very easy reaction conditions, simple work-up, excellent yields, high purity of the desired product, short reaction time and one-pot reaction to synthesize Fe3O4@SiO2-HBP-FeCl3. The recycling studies revealed that catalyst could be easily recovered using an external magnet and reused five times without significant loss of its catalytic activity.

N-Propyl benzoguanamine sulfonic acid supported on magnetic Fe3O4 nanoparticles: A novel and efficient magnetically heterogeneous catalyst for the synthesis of 1,8-dioxo-decahydroacridine derivatives

In this study, N-propyl-benzoguanamine-SO3H-stabilized magnetic nanoparticles were prepared as a new heterogeneous acid catalyst in accordance with the principles of green chemistry. The new catalyst is used for the synthesis of derivatives of

ZnII doped and immobilized on functionalized magnetic hydrotalcite (Fe3O4/HT-SMTU-ZnII): A novel, green and magnetically recyclable bifunctional nanocatalyst for the one-pot multi-component synthesis of acridinediones under solvent-free conditions

ZnII doped and immobilized on functionalized magnetic hydrotalcite (Fe3O4/HT-SMTU-ZnII) was prepared for the first time as a stable, long-lived, highly efficient and exceptional reusable magnetic nanocatalyst for the one-pot multi-component synthesis of acridinediones as an important class of heterocyclic compounds. The synthesized catalyst was characterized by various spectroscopic and microscopic techniques such as Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, Brunauer, Emmett and Teller (BET) surface area analysis, temperature programmed desorption (TPD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), inductively coupled plasma atomic emission spectroscopy (ICP-OES) and CHNS analysis. The results of characterizations showed the superparamagnetic nature of the catalyst with an average particle size of 20-60 nm which is plate-like in shape. Also, the results of the TPD analysis showed that the nanocatalyst has both acidic sites (site density: 22.66 mmol g-1) and basic sites (site density: 8.49 mmol g-1), and can act as a bifunctional nanocatalyst. The loading amount of ZnII (doped and immobilized) on functionalized magnetic hydrotalcite was indicated to be 4 mmol g-1, obtained from the ICP-OES analysis. The catalytic activity of this new magnetic nanocatalyst (Fe3O4/HT-SMTU-ZnII) was examined in the multi-component reaction of aromatic aldehydes, dimedone, and various primary amines or NH4+ under solvent-free conditions towards the preparation of acridinedione derivatives in a short period of time. In all the cases, the catalyst could be easily recovered magnetically for at least six runs and the obtained product was isolated using a simple work-up procedure. In our protocol, the solvent-free conditions avoid the problems such as cost, handling, safety and pollution which are related to solvent use. The characteristics of the present methodology make the reaction suitable for scale-up and commercialization.

Immobilization of organofunctionalized silica (SiMPTMS) with biphenyl-2,2′-dioic acid and investigation of its catalytic property for one-pot tandem synthesis of acridine-1,8-dione derivatives

Abstract: MPTMS-functionalized silica immobilized with biphenyl-2,2′-dioic acid, an efficient heterogeneous catalyst, was synthesized and characterized by various spectroscopic techniques such as FTIR, TGA, TEM and SEM. The catalytic activity of the synth

Synthesis, Structure, and Biological Activities of 10-Substituted 3,3,6,6-Tetramethyl-9-Aryl-3,4, 6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione Derivatives

A series of 10-substituted-3,3,6,6-tetramethyl-9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5 H)-dione derivatives 2 were synthesized by reaction of compounds 1 with amines. The compounds 1 were effectively prepared by 5,5-dimethylcyclohexane-1,3-dione an

P-Sulfonic acid calix[4]arene as an efficient and reusable catalyst for the synthesis of acridinediones and xanthenes

p-Sulfonic acid calix[4]arene has been found to be an efficient catalyst for the synthesis of acridinediones and xanthenes under mild conditions in excellent yields. The present approach offers the advantages of simple methodology, short reaction time, an

An environmentally benign catalytic method for versatile synthesis of 1,4-dihydropyridines via multicomponent reactions

The synthesis of diverse 1,4-dihydropyridines have been achieved via the multicomponent reactions of aldehydes, enaminones and amines. The reactions have been smoothly performed in water to provide all products with moderate to excellent yields by using l

Fe3O4 nanoparticles: As an efficient, green and magnetically reusable catalyst for the one-pot synthesis of 1,8-dioxo- decahydroacridine derivatives under solvent-free conditions

An efficient and environmentally friendly method for the one-pot synthesis of 1,8-dioxo-decahydroacridines has been developed in the presence of Fe 3O4 nanoparticles. The multicomponent reactions of aldehydes, dimedone and amines wer

FSG-Hf(NPf2)4 catalyzed, environmentally benign synthesis of 1,8-dioxo-decahydroaridines in water-ethanol

An efficient, eco-friendly and simple work-up procedure for the synthesis of 1,8-dioxo-decahydroacridines has been developed through one-pot condensation reaction of aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedion and different aromatic amine or ammon