40499-78-3

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 540-80-7 tert.-butylnitrite 
• 6832-17-3 2-diazo-1-(4-methoxyphenyl)ethanone 
• 46318-58-5 4-methoxybenzoylnitromethane 

Downstream Products

• 65239-17-0 4,7-di(p-methoxyphenyl)-1,2,5-oxadiazolo<3,4-d>pyridazine 
• 65239-15-8 bis-(4-methoxy-phenyl)-butanetetraone 2,3-dioxime 
• 100-09-4 4-methoxybenzoic acid 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 65239-16-9 C,C'-bis-(4-methoxy-phenyl)-C,C'-furazan-3,4-diyl-bis-methanone 

Relevant academic research and scientific papers

Catalyst-free formation of nitrile oxides and their further transformations to diverse heterocycles

The formation of nitrile oxides with diazocarbonyl compounds by nitrosyl transfer from tert-butyl nitrite under mild conditions and without the use of a catalyst or an additive is reported. This transformation is broadly applicable to the synthesis of fur

Fluorescent dye

To provide a fluorescent dye having higher fluorescence intensity.SOLUTION: A fluorescent dye comprises a triazole condensed ring compound represented by general formula (I). In the general formula (I), R1, R2 independently represent a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group; A1 is at least one functional group selected from the group consisting of -(CH=CRa)n- (n is an integer of 1-6), -(CH2)n- (n is an integer of 1-6), -(AO)n- (AO is a C2-6 alkylene oxide, n is an integer of 1-10), -NHCOO-, -CONH-, -CONH(Rb)-, -COO-, -SO2 NH-, -HN-C(=NH)-NH-, -O-, -S-, -NRb-, -Ar- (Ar is an aryl group or a heteroaryl group), -CO-Ar-NRb-; Ra is a hydrogen atom or a C1-4 alkyl group; Rb is a C1-4 alkyl group; B1 is an alkyl ester group, an alkyl ether group, an alkyl amide group, or a (C2-6) alkylene oxide adduct thereof, or a reactive group with a biomolecule optionally having a linking group to A1.SELECTED DRAWING: None

Method for directly synthesizing furoxan from methyl ketone

The invention discloses a method for directly synthesizing furoxan from methyl ketone, and belongs to the technical field of organic chemical synthesis. According to the method, methyl ketone is usedas a raw material, methyl ketone and a green nitration r

Fluorescent dye

PROBLEM TO BE SOLVED: To provide a fluorescent dye that can be produced at reduced cost, and has higher fluorescence intensity even in a solid state. SOLUTION: A fluorescent dye contains an azole derivative such as 4,7-bis(4-methoxyphenyl)-6-(N-methyl-N-s

Solvent-free mechanochemical synthesis of diacylfuroxans

Acetophenones with a variety of substituents could be converted to diacylfuroxans in a solvent-free reaction by combining the reagents Fe(NO3)3·9H2O and P2O5 under high-speed ball milling. This reacti

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of, among others, drug-resistant cancers. Although most GPX4 inhibitors rely on a chloroacetamide moiety to modify covalently the protein's catalytic selenocysteine residue, the discovery and mechanistic elucidation of structurally diverse GPX4-inhibiting molecules have uncovered novel electrophilic warheads that bind and inhibit GPX4. Here, we report our discovery that diacylfuroxans can act as masked nitrile oxide prodrugs that inhibit GPX4 covalently with unique cellular and biochemical reactivity compared to existing classes of GPX4 inhibitors. These observations illuminate a novel molecular mechanism of action for biologically active furoxans and also expand the collection of reactive groups capable of targeting GPX4.

Synthesis of Furoxans and Isoxazoles via Divergent [2 + 1 + 1 + 1] Annulations of Sulfoxonium Ylides and tBuONO

We have presented a simple and new method for the divergent assembly of furoxans and isoxazoles in which the [2 + 1 + 1 + 1] annulation reaction of sulfoxonium ylides is reported for the first time. When the reaction was performed using tBuONO

Fluorescent dye

PROBLEM TO BE SOLVED: To provide a fluorescent dye that has improved water solubility and thus provides high fluorescence intensity. SOLUTION: A fluorescent dye of the present invention is an azole derivative having a polyoxyalkylene group represented by general formula E-O-(CH2CH2O)p-, where E is a C1-4 alkyl group and p is an integer from 1 to 40. The dye has improved water solubility and provides high fluorescence intensity. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT

LABELING DYE FOR BIOMOLECULE, LABELING KIT, AND METHOD FOR DETECTING BIOMOLECULE

A labeling dye of the present invention includes a coloring portion comprising an organic EL-dye, a bonding portion to be bonded with a biomolecule and a spacer portion for linking the coloring portion and the bonding portion. The present invention provid