40503-87-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(3'-fluorophenyl)-cyclohexanone is used as a building block for the preparation of various pharmaceuticals due to its pharmacological activities and potential in the development of new drugs.
Used in Agrochemical Industry:
4-(3'-fluorophenyl)-cyclohexanone is used as a key intermediate in the synthesis of agrochemicals, contributing to the development of effective and novel agrochemical products.
Used in Specialty Chemicals Industry:
4-(3'-fluorophenyl)-cyclohexanone is used as a precursor in the production of specialty chemicals, enabling the creation of unique and high-value chemical compounds.
Used in Organic Synthesis:
4-(3'-fluorophenyl)-cyclohexanone is used as a versatile intermediate in organic synthesis, facilitating the preparation of a wide range of bioactive compounds and functional materials.
Used in Drug Development:
4-(3'-fluorophenyl)-cyclohexanone is used as a crucial component in the development of new drugs, leveraging its pharmacological properties and potential applications in medicinal chemistry.

Upstream product

• 217476-14-7 8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decane 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 680596-79-6 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 
• 768-35-4 3-fluorophenylboronic acid 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 1073-06-9 3-fluorobromobenzene 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 
• 13482-22-9 4-hydroxycyclohexanone 
• 40503-83-1 4-(m-Fluorphenyl)-4-hydroxy-cyclohexanon 

Downstream Products

• 1231258-46-0 C₁₄H₁₅FO₃ 
• 1402080-51-6 5-(3-fluorophenyl)oxepan-2-one 

Relevant academic research and scientific papers

HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS

The present invention is directed to heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Desymmetrizing Isomerization of Alkene via Thiazolinyl Iminoquinoline Cobalt Catalysis

We report a cobalt-catalyzed desymmetrizing isomerization of exo-cyclic alkenes to generate chiral 1-methylcyclohexene derivatives with good yields and enantioselectivities. A novel chiral thiazolinyl iminoquinoline ligand and its cobalt complex were desi

5-ALKYL PYRROLIDINE OREXIN RECEPTOR AGONISTS

The present invention is directed to 5-alkyl pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Method for synthesizing trans-4-alkylcyclohexyl benzene structure liquid crystal intermediates and monomers

The invention discloses a method for synthesizing trans-4-alkylcyclohexyl benzene structure liquid crystal intermediates and monomers and belongs to the technical field of trans-cyclohexyl benzene liquid crystal. The method comprises the following steps:

SUBSTITUTED PIPERIDINE COMPOUND AND USE THEREOF

Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist act

NOVEL INHIBITORS

The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein R1, R2, R3, R4 and R5 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N- terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

Enantioselective baeyer-villiger oxidation: Desymmetrization of meso cyclic ketones and kinetic resolution of racemic 2-arylcyclohexanones

Catalytic enantioselective Baeyer-Villiger (BV) oxidations of racemic and meso cyclic ketones were achieved in the presence of chiral N,N'-dioxide-Sc III complex catalysts. The BV oxidations of prochiral cyclohexanones and cyclobutanones afforded series of optically active μ- and γ-lactones, respectively, in up to 99% yield and 95% ee. Meanwhile, the kinetic resolution of racemic 2-arylcyclohexanones was also realized via an abnormal BV oxidation. Enantioenriched 3-aryloxepan-2-ones, whose formation is counter to the migratory aptitude, were obtained preferentially. Both the lactones and the unreacted ketones were obtained with high ee values.

Enantioselective baeyer-villiger oxidation: Desymmetrization of meso cyclic ketones and kinetic resolution of racemic 2-arylcyclohexanones

Catalytic enantioselective Baeyer-Villiger (BV) oxidations of racemic and meso cyclic ketones were achieved in the presence of chiral N,N'-dioxide-Sc III complex catalysts. The BV oxidations of prochiral cyclohexanones and cyclobutanones afforded series of optically active μ- and γ-lactones, respectively, in up to 99% yield and 95% ee. Meanwhile, the kinetic resolution of racemic 2-arylcyclohexanones was also realized via an abnormal BV oxidation. Enantioenriched 3-aryloxepan-2-ones, whose formation is counter to the migratory aptitude, were obtained preferentially. Both the lactones and the unreacted ketones were obtained with high ee values.