4052-69-1

Upstream product

• 1256-06-0 (2S,5R,6R)-benzyl-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 
• 132-98-9 penicillin V potassium 
• 100-39-0 benzyl bromide 

Downstream Products

• 66193-65-5 6,6-bis-ethoxycarbonylamino-1β-oxo-1λ⁴-penicillanic acid benzyl ester 
• 4888-90-8 phenoxymethylpenicillin sulfoxide 
• 69576-06-3 (R)-3-methyl-2-((1R)-7-oxo-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzyl ester 
• 75520-53-5 (-)-isodehydrovaline benzyl ester hydrochloride 
• 73910-37-9 benzyl 7β-phenylacetylamino-3-methyl-1-carba-1-dethia-3-cephem-4-carboxylate 
• 73973-65-6 (6R,7R)-7-Methoxy-7-{2-(4-methoxy-benzyloxycarbonyl)-2-[4-(4-methoxy-benzyloxy)-phenyl]-acetylamino}-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 73910-31-3 {(2R,3S)-2-[4-(1-Methyl-1H-tetrazol-5-ylsulfanyl)-3-oxo-butyl]-4-oxo-3-phenylacetylamino-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzyl ester 
• 73935-56-5 benzyl 2-<3β-phenylacetylamino-4β-(4-chloroacetoxy-3-oxobutyl)-2-oxoazetidin-1-yl>-2-triphenylphosphorane-diylethanoate 
• 73910-45-9 {(2R,3S)-2-[2-(2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-4-oxo-3-phenylacetylamino-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzyl ester 
• 73910-46-0 [(2R,3S)-2-(3,4-Dihydroxy-butyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzyl ester 
• 76284-31-6 (6R,7S)-7-((R)-2-tert-Butoxycarbonylamino-2-phenyl-acetylamino)-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 73910-51-7 (6R,7R)-7-{[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 73910-50-6 7-[(Z)-3,5-Di-tert-butyl-4-oxo-cyclohexa-2,5-dienylidenemethylimino]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 73910-47-1 [(3S,4R)-2-Oxo-4-(3-oxo-propyl)-3-phenylacetylamino-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzyl ester 

Relevant academic research and scientific papers

OXIDATION STUDIES ON BETA-LACTAM ANTIBIOTICS SYNTHESIS OF PHENAM AND CEPHEM SULFOXIDES AND SULFONES

Penicillin and cephalosporin sulfoxides are conveniently prepared by oxidation of the respective penicillin or cephalosporin in methylene chloride using hydrogen peroxide and acetic acid.Replacement of the acetic acid by formic acid produces the respectiv