1256-06-0

Upstream product

• 100-39-0 benzyl bromide 
• 132-98-9 penicillin V potassium 
• 80282-02-6 benzyl (2S,5R,6R)-(Z)-7-methoxycarbonylmethylene-3,3-dimethyl-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>-heptane-2-carboxylate 
• 80282-03-7 benzyl (2S,5R,6R)-(E)-7-methoxycarbonylmethylene-3,3-dimethyl-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>-heptane-2-carboxylate 
• 85380-71-8 lithium (2S,5R,6R)-7-methoxycarbonyl-(E)-methylene-3,3-dimethyl-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>-heptane-2-carboxylate 

Downstream Products

• 4052-69-1 penicillin-V β-sulfoxide benzyl ester 
• 51056-25-8 (2S,5R,6S)-Benzyl 6-Hydroxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 89971-88-0 benzyl (3S,5R,6R)-6-phenoxyacetamido-penicillanate 1,1-dioxide 
• 112789-93-2 benzyl (2S,5R,6R)-(Z)-7-benzyloxycarbonylmethylene-3,3-dimethyl-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>-heptane-2-carboxylate 
• 112711-39-4 benzyl (2S,5R,6R)-(E)-7-benzyloxycarbonylmethylene-3,3-dimethyl-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>-heptane-2-carboxylate 
• 77-80-5 bis(triphenyltin) sulfide 
• 124870-86-6 (R)-3-Methyl-2-[(S)-2-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-butyric acid benzyl ester 
• 124870-87-7 C₄₁H₄₀N₂O₅SSn 
• 86269-29-6 (Z)-(2S,8R,9S)-3,3,6-Trimethyl-10-oxo-9-(2-phenoxy-acetylamino)-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester 
• 42879-04-9 Benzyl (1S,3S,6R)-6-(phenoxyacetylamino)penicillanate 1-oxide 
• 124870-88-8 C₂₃H₂₄⁽²⁾H₂N₂O₅ 
• 80282-04-8 benzyl (2S,5R,6R)-(Z)-7-cyanomethylene-3,3-dimethyl-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>-heptane-2-carboxylate 
• 80282-05-9 benzyl (2S,5R,6R)-(E)-7-cyanomethylene-3,3-dimethyl-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>-heptane-2-carboxylate 
• 85932-83-8 N-benzyloxycarbonyl-α-benzyl-δ-(L-α-aminoadipyl)-S-acetyl-L-cysteinyl-D-3,4-didehydrovaline benzyl ester 

Relevant academic research and scientific papers

THE USE OF LIPOPHILIC BETA-LACTAM ANTIBIOTICS AND CARBOXYLATE ESTERS FOR THE TREATMENT OF BACTERIAL INFECTIONS WITHIN CITRUS AND OTHER PLANT SPECIES

Disclosed is method for converting a beta-lactam antibiotic into a “masked” beta-lactam antibiotic to permit it to cross the waxy cuticle of a plant and then subsequently unmasking the beta-lactam and converting it into an active beta-lactam antibiotic in

CEPHALOSPORIN DERIVATIVES AND METHODS OF USE

This invention provides cephalosporin derivatives for killing or inhibiting the spread of microorganisms such as non-replicating Mycobacterium tuberculosis and in the treatment of infectious disease.

Wittig Reactions with β-Lactam Carbonyl Functions. The Effect of C-7 Substitution on the Chemistry of Penicillins and Clavulanic Acid Derivatives.

The Wittig reaction of phosphoranes and phosphonates with the carbonyl function of mono- and bicyclic β-lactams has been studied and the inluence of phosphorane and β-lactam reactivities on the outcome of the reaction noted.The utility and general chemist

1-Aza-[3.2.0]-bicycloheptane-2-carboxylic acid, ester or salt thereof

A 1-aza[3.2.0]bicycloheptan-2-carboxylic acid or salt or ester thereof having a substituent at position 7 of the formula: wherein R1 and R2 are independently hydrogen, halogen or an organic group.

THE SYNTHESIS OF L-α-AMINOADIPYL-L-CYSTEINYL-D-3,4-DIDEHYDROVALINE, A POTENT INHIBITOR OF ISOPENICILLIN SYNTHETASE

The title peptide (1) has been synthesized and incubated with an active cell-free extract of Cephalosporium acremonium, no conversion to active antibiotics was observed; however on co-incubation with the Arnstein tripeptide (ACV) (2), strong inhibition of

Wittig Reactions with β-Lactam Carbonyls: A Convenient Means of Protection. X-Ray Crystal Structure of p-Nitrobenzyl-(2R,5R)-Z-7-Methoxycarbonylmethylene-Z-3-(β-phthalimidoethylidene)-4-oxa-1-azabicycloheptane-2-carboxylate

Clavulanic acid derivatives and penicillin V esters undergo Wittig reactions at the β-lactam carbonyl and the β-lactam can be regenerated by low-temperature ozonolysis; the crystal structure of one of the products is reported.