40531-91-7

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 
• 74128-90-8 2,2,2',2'-Tetrachlor-1,1'-diphenyl-2,2'-trithiobis(ethanon) 
• 124-40-3 dimethyl amine 
• 1468-28-6 4-benzoylmorpholine 
• 758-16-7 N,N-dimethylthioformamide 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 7436-90-0 2,2-dibromostyrene 
• 2461-75-8 benzoylmethyl disulfide 

Downstream Products

• 184833-13-4 Methanesulfonic acid (R)-1-methyl-3-phenyl-2-thioxo-azetidin-3-yl ester 
• 184833-20-3 (S)-3-Azido-1-methyl-3-phenyl-azetidine-2-thione 
• 87342-60-7 N,N-dimethyl-2-phenyl-2-thioxothiacetamide 

Relevant academic research and scientific papers

The thioamidation ofgem-dibromoalkenes in an aqueous medium

The direct integration of sulphur and amine groups with 1,1-dibromoalkenes for thioamide synthesis has been achieved in an aqueous medium. The presented green protocol emphasizes the suitability of aqueous media for the thioamidation reaction and enables greater selectivity with synthetic utility. A wide range of thioamides in moderate to excellent yields has been achieved using readily available starting materials, with the use of no organic solvents, catalysts, or additives.

Synthesis of α-Keto Thioamides by Metal-Free C-C Bond Cleavage in Enaminones Using Elemental Sulfur

An unprecedented method for cleaving the C-C bond in N,N-disubstituted enaminones in the presence of elemental sulfur and N,N-dimethyl-4-aminopyridine is disclosed. Without using any metal catalyst or additive, the cascade functionalization of both C?C an

Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation

An ambient temperature continuous flow method for nucleophilic amidation and thioamidation is described. Deprotonation of formamides by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophi

Na2S-mediated thionation: An efficient access to secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines

The task of this paper is to provide an efficient process for synthesis of secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines using Na2S as an effective catalyst. A plausible role for Na2S in the reaction of arylglyoxals with primary amines is proposed.

Summary - α-Thioxothioamides : [4 + 2] cycloaddition reactions with dimethyl acetylenedicarboxylate and methyl propiolate

The title compounds are prepared from methyl ketones through a three-step reaction: chloration with thionyl chloride; amination of the resulting α-chloro-β-oxosulfenyl chlorides; and thionation of α-oxothioamides with Lawesson's reagent. Two competitive h

α-Oxo- and α-Thioxothioamides from Methyl Ketones

Mixtures of α-(chloro)sulfenyl chlorides 5 and trisulfides 6 are obtained from the reaction of thionyl chloride with methyl ketones in the presence of pyridine.From these mixtures as well as from the pure trisulfides 6, with amines the α-oxothioamides 1-4