406909-97-5Relevant academic research and scientific papers
Synthesis and Enzymatic Kinetic Resolution of α,α -Disubstituted Cyclic Hydroxy Nitriles
Levy, Laura M.,Gotor, Vicente
, p. 2601 - 2602 (2007/10/03)
Herein, we describe the diastereoselective synthesis of five- and six-membered α,α-disubstituted cyclic β-hydroxy nitriles and their resolution via enzymatic transesterification. By this method, all possible stereoisomers were obtained in enantiopure form and high yield.
Preparation of enantiopure ketones and alcohols containing a quaternary stereocenter through parallel kinetic resolution of β-keto nitriles
Dehli, Juan R.,Gotor, Vicente
, p. 1716 - 1718 (2007/10/03)
Racemic 1-methyl-2-oxocycloalkanecarbonitriles have been subjected to bioreduction by the fungus Mortierella isabellina NRRL 1757 through a parallel kineticresolution process. The u and l alcohols thus obtained (up to >99% ee) were easily separated and oxidized to the R and S ketones, respectively. The process can be then repeated so that both enantiomers of the ketone and two epimers of the alcohol can be obtained in their enantiopure forms.
