406913-93-7

Basic information

• Product Name: (2S)-1,4-Dioxan-2-yl-methanol
• Synonyms: (2S)-1,4-Dioxan-2-yl-methanol;(2S)-1,4-Dioxane-2-methanol;(S)-(1,4-Dioxan-2-yl)Methanol;(S)-2-(Hydroxymethyl)-1,4-dioxane
• CAS NO: 406913-93-7
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• Mol File: 406913-93-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 208.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.102
• Storage Temp.: 2-8°C
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: (2S)-1,4-Dioxan-2-yl-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1,4-Dioxan-2-yl-methanol(406913-93-7)
• EPA Substance Registry System: (2S)-1,4-Dioxan-2-yl-methanol(406913-93-7)

Safety Data

• RIDADR: UN1993
• Hazardous Substances Data: 406913-93-7(Hazardous Substances Data)

Usage

General Description

(2S)-1,4-Dioxan-2-yl-methanol is a chemical compound with the molecular formula C5H10O3. It is a colorless liquid with a faint, pleasant odor, and it is used as a solvent in various chemical reactions and processes. (2S)-1,4-Dioxan-2-yl-methanol is also used in the synthesis of pharmaceuticals and agrochemicals. It has the potential to act as a chiral auxiliary in asymmetric synthesis, making it an important compound for the production of enantiomerically pure compounds. Additionally, (2S)-1,4-Dioxan-2-yl-methanol is used in research and development of new materials and products due to its versatile and useful properties.

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 107-07-3 2-chloro-ethanol 
• 861852-08-6 (2R)-2-[(2-chloroethoxy)methyl]oxirane 
• 27905-76-6 2-(2-chloroethoxy)-3-chloropropan-2-ol 
• 917882-63-4 (2S)-2-[(benzyloxy)methyl]-1,4-dioxane 
• 406913-84-6 2-hydroxymethyl-1,4-dioxane hydrogen phthalate 
• 18371-74-9 1-chloro-3-(2-hydroxyethoxy)-2-propanol 
• 29908-11-0 (+/-)-2-(hydroxymethyl)-1,4-dioxane 
• 934346-53-9 (R)-1-(2-chloroethoxy)-3-chloropropan-2-ol 
• 934346-80-2 (S)-2-((2-chloroethoxy)methyl)oxirane 
• 406913-89-1 Phthalic acid mono-(R)-1-[1,4]dioxan-2-ylmethyl ester 

Downstream Products

• 1067230-84-5 [(2R)-1,4-dioxan-2-yl]methyl 4-methylbenzenesulfonate 
• 1337470-52-6 (S)-(1,4-dioxan-2-yl)methanamine 
• 1569298-20-9 C₁₀H₁₉NO₄ 

Relevant articles and documents

Meso-Tetra(dioxanyl)porphyrins: Neutral, low molecular weight, and chiral porphyrins with solubility in aqueous solutions

The synthesis of the low-molecular weight, meso-Tetra(dioxan-2-yl)porphyrin with considerable solubility in aqueous solution is described. The key intermediate dioxan-2-carbaldehyde is accessible in either racemic or in stereo-pure forms from commercially available starting materials in three steps. Using 4 × 1 or 2 + 2-Type syntheses provide the porphyrin in modest yields. While the racemic aldehyde created an intractable mixture of diastereomers, the enantiopure aldehyde created a single enantiomer of the target porphyrin. The porphyrin was spectroscopically characterized. As its free base or zinc complex, it showed excellent solubility properties in organic and aqueous solvents, though free water-solubility was not achieved. The work expands on the availability of chiral porphyrins and neutral porphyrins with considerable solubility in aqueous solution.

1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES

The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

Method for Producing Diarylpyridine Derivatives

The present invention relates to a novel method for producing diarylpyridine derivatives, and the object of the present invention is to provide a novel, industrially useful method. The present inventors developed a novel method for synthesizing pyridine r