406913-84-6

Basic information

• Product Name: 2-hydroxymethyl-1,4-dioxane hydrogen phthalate
• Synonyms: 2-hydroxymethyl-1,4-dioxane hydrogen phthalate
• CAS NO: 406913-84-6
• Molecular Weight: 266.251
• Mol File: 406913-84-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxymethyl-1,4-dioxane hydrogen phthalate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxymethyl-1,4-dioxane hydrogen phthalate(406913-84-6)
• EPA Substance Registry System: 2-hydroxymethyl-1,4-dioxane hydrogen phthalate(406913-84-6)

Safety Data

• Hazardous Substances Data: 406913-84-6(Hazardous Substances Data)

Upstream product

• 18371-74-9 1-chloro-3-(2-hydroxyethoxy)-2-propanol 
• 29908-11-0 (+/-)-2-(hydroxymethyl)-1,4-dioxane 
• 85-44-9 phthalic anhydride 

Downstream Products

• 406913-93-7 [(2S)-1,4-dioxan-2-yl]methanol 
• 406913-88-0 (R)-(-)-2-hydroxymethyl-1,4-dioxane 
• 406913-91-5 Phthalic acid mono-(S)-1-[1,4]dioxan-2-ylmethyl ester 
• 406913-89-1 Phthalic acid mono-(R)-1-[1,4]dioxan-2-ylmethyl ester 

Relevant articles and documents

2-Hydroxymethyl-1,4-dioxane: Synthesis, resolution and determination of the absolute configurations of the enantiomers

2-Hydroxymethyl-1, 4-dioxane 3 was resolved via salt formation between its hydrogen phthalate and (R)- or (S)-1-phenylethylamine, selective crystallization of the resultant diastereomeric mixtures and subsequent recovery of its enantiomers by saponification. The progress of the resolution was followed by chiral HPLC and the absolute stereochemistry of the two enantiomers determined by comparison of their specific rotations with that of (R)-3 synthesized from enantiomerically pure (R)-1-O-benzylglycerol. The results of the synthesis of 3 and of its resolution are discussed and compared with those previously obtained for 1,2-isopropylidene glycerol evaluating the consequences of replacement of ispropylidene with an ethylene bridge.