406939-93-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone is used as a protected form of Plerixafor for the preparation of Plerixafor derivatives. Plerixafor is a drug that modulates the CXCR4 receptor, which plays a role in various biological processes, including cell migration and cancer progression. The protection of Plerixafor with multiple trifluoroacetyl groups allows for its stabilization and controlled release in pharmaceutical applications.
Used in Research and Development:
In the field of research and development, 1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone serves as an important intermediate for the synthesis of various Plerixafor-related compounds. Its unique structure and functional groups make it a valuable tool for exploring new drug candidates and understanding the mechanisms of action of Plerixafor and its derivatives.
Used in Drug Delivery Systems:
Similar to Gallotannin, 1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone can potentially be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. The use of nanoparticles or other carriers could enhance the delivery of Plerixafor and its derivatives to specific target cells or tissues, increasing their efficacy and reducing potential side effects.

Upstream product

• 623-25-6 p-Xylylene dichloride 
• 406939-92-2 1,1′,1″-(1,4,8,11-tetraazacyclotetradecane-1,4,8-triyl)tris-(2,2,2-trifluoroethan-1-one) 
• 295-37-4 1,4,8,11-Tetraazacyclotetradecane 
• 623-24-5 1,4-bis(bromomethyl)benzene 

Downstream Products

• 110078-46-1 1-[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)benzyl]-1,4,8,11-tetraazacyclotetradecane 

Relevant academic research and scientific papers

Dendrimers based on a bis-cyclam core as fluorescence sensors for metal ions

We have synthesized a novel dendrimer (1) based on two covalently linked cyclam units as a core appended to six branches, each one consisting of one dimethoxybenzene and two naphthyl units (cyclam = 1,4,8,11- tetraazacyclotetradecane). Such a dendrimer shows three fluorescence bands which can be assigned to naphthyl localized excited states (λmax = 336 nm), naphthyl excimers (λmax ca. 390 nm), and naphthyl-amine exciplexes (λmax = 510 nm). Protonation or complexation of the bis-cyclam core with Zn2+ does not affect the absorption spectrum of the dendrimer, but causes noticeable changes in the fluorescence intensity of the three component bands. Complexation with Cu 2+ not only causes changes in the relative intensities of the fluorescence bands, but also the appearance of a new absorption band in the near UV spectral region. Analysis of the titration curves has allowed us to obtain clear evidence for the formation of 1 : 1 (1(H+), [Zn(1)] 2+, [Cu(1)]2+) and 2 : 1 (1(2H+), [Zn 2(1)]4+, [Cu2(1)]4+) species. Comparison with the behaviour of a previously investigated parent monocyclam dendrimer (2) suggests that in the 1 : 1 species of 1 both the cyclam units are involved in the complexation with Zn2+ and Cu2+. The Royal Society of Chemistry 2005.

Plerixafor crystal form D, plerixafor intermediate crystal form S and preparation methods and application thereof

The invention relates to a plerixafor crystal form D, a plerixafor intermediate crystal form S and preparation methods and application thereof. By preparing the plerixafor crystal form D, a plerixafor raw material medicine which is easier to store is obtained, the plerixafor crystallization process is simplified, and the plerixafor crystal form D is suitable for large-scale production. By preparing the plerixafor key intermediate crystal form S, the purification process of the intermediate is simplified, and the purity of the prepared plerixafor raw material medicine is improved.

64Cu-AMD3100-A novel imaging agent for targeting chemokine receptor CXCR4

CXCR4 is a chemokine receptor which has been shown to be exploited by various tumors for increased survival, invasion, and homing to target organs. We developed a one step radiosynthesis for labeling the CXCR4-specific antagonist AMD3100 with Cu-64 to pro

Facile N-1 protection of cyclam, cyclen and 1,4,7-triazacyclononane

An exceptionally high yielding method for the tri-protection of cyclam and cyclen using ethyl trifluoroacetate is described. The selective reaction also applies to the di-protection of 1,4,7-triazacyclononane. The application of this method in the synthesis of AMD3100, a clinical candidate for stem cell mobilization is presented.