40740-33-8Relevant academic research and scientific papers
PREPARATION AND USES OF REACTIVE OXYGEN SPECIES SCAVENGER DERIVATIVES
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Page/Page column 83; 88-89, (2019/03/07)
Compounds of Formula (I) a or (I) b: including certain quinone derivatives, and the corresponding pharmaceutical compositions, which may serve to modulate ferroptosis in a subject. Also disclosed herein are the preparations of these compounds and pharmaceutical compositions and their potential uses in the manufacture of a medicament in reducing reactive oxygen species (ROS) in a cell and for preventing, treating, ameliorating certain related disorder or a disease.
Novel ipso-Substitution of p-Sulfinylphenols through the Pummerer-Type Reaction: A Selective and Efficient Synthesis of p-Quinones and Protected p-Dihydroquinones
Akai, Shuji,Takeda, Yoshifumi,Iio, Kiyosei,Takahashi, Kenji,Fukuda, Nobuhisa,Kita, Yasuyuki
, p. 5526 - 5536 (2007/10/03)
The treatment of p-sulfmylphenols 3a-q with trifluoroacetic anhydride caused a Pummerer-type reaction on aromatic rings and concomitant desulfurization to give mixtures of the corresponding p-dihydroquinones 9 and p-quinones 10, which were subsequently oxidized under mild conditions to provide high yields of p-quinones 10. On the other hand, the treatment of p-(phenylsulfinyl)-phenyl ethers 6 with trifluoroacetic anhydride in the presence of styrene caused the direct ipso-substitution of the sulfinyl groups into trifluoroacetoxy groups, giving the protected dihydroquinones 14 in high yields. Both types of reactions were generally completed below room temperature within 1 h and compatible with various functional groups such as the allyl, carbonyl, ester, amide, and silyloxy groups. The preparation of the p-sulfmylphenols 3 and the silyl ethers 6 is also described through p-specific thiocyanation of phenols followed by the Grignard reaction and oxidation.
Electroorganic Synthesis, 58. Synthesis of Substituted Benzoquinones and their Use for Mediated Electrochemical Conversions
Riering, Helmut,Schaefer, Hans J.
, p. 859 - 874 (2007/10/02)
Hydroxy- (1a-3a) and hydroxyalkyl-substituted benzoquinones (6a-8a, 27a), suited to be immobilized by esterification with polyacrylic acid, are prepared.Their cathodic reduction potential Ep,c (1) correlates linearly with their substituent constant.The cathodic reduction of dioxygen and the palladium(II)-catalyzed anodic oxidation of alkenes are mediated by the benzoquinones 7b, 8b and 27b, respectively. - Key Words: Benzoquinones, substituted / Cyclic voltammetry / Cathodic dioxygen reduction, mediated / Anodic Wacker oxidation, mediated
SYNTHESIS OF DIQUINONE DERIVATIVES OF DEUTEROPORPHYRIN IX FOR THE STUDY OF THE FIRST STAGE IN THE PROCESS OF PHOTOSYNTHESIS
Borovkov, V. V.,Evstigneeva, R. P.,Makova, S. Z.
, p. 142 - 147 (2007/10/02)
Diquinone derivatives of deuteroporphyrin IX containing covalent bridges of different lengths between the chromophores have been synthesized.The compounds were prepared by the condensation of hydroxy-quinones with deuteroporphyrin IX using a mixed anhydri
Aralkyl carboxylic acid compounds
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, (2008/06/13)
Novel compounds of the formulae STR1 wherein R represents lower alkyl or lower alkoxy, A represents --CH2 --, --CO-- or STR2 n represents an integer of 1 to 8, X represents hydrogen or hydroxyl which may be protected and Y represents hydroxyl which may be protected, and their esters show an excellent action on the lysosomal membranes of cells, and exhibit excellent pharmacological activities such as physiologic host defense control activity, especially immuno-potentiating activity.
