903560-42-9

Basic information

• Product Name: methyl 4-phenyl-1H-pyrrole-2-carboxylate
• CAS NO: 903560-42-9
• Molecular Weight: 201.225
• Mol File: 903560-42-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 4-phenyl-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-phenyl-1H-pyrrole-2-carboxylate(903560-42-9)
• EPA Substance Registry System: methyl 4-phenyl-1H-pyrrole-2-carboxylate(903560-42-9)

Safety Data

• Hazardous Substances Data: 903560-42-9(Hazardous Substances Data)

Upstream product

• 40740-41-8 methyl 4-iodo-1H-pyrrole-2-carboxylic acid ester 
• 98-80-6 phenylboronic acid 
• 156237-78-4 4-bromopyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 934-05-4 methyl 4-bromo-1H-pyrrole-2-carboxylate 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 536-74-3 phenylacetylene 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 7089-34-1 ((Z)-3-Dimethylamino-2-phenyl-allylidene)-dimethyl-ammonium; perchlorate 
• 67-56-1 methanol 
• 1173715-77-9 tert-butyl (2S,4R)-4-hydroxy-4-phenyl-1-p-toluenesulfonylpyrrolidine-2-carboxylate 

Relevant articles and documents

An efficient synthesis of aryl-substituted pyrroles by the Suzuki–Miyaura coupling reaction of SEM-protected pyrroles

An efficient arylation of SEM-protected pyrroles by the Suzuki–Miyaura coupling reaction has been developed. The reaction can be carried out under mild conditions to provide aryl-substituted pyrroles in moderate to excellent yields. The scope and limitations of the methodology were evaluated, and the reaction was tolerant of a wide range of functionalities. Compared to the reported methods, the protocol has some advantages, such as commercially available materials, no debrominated by-products being formed, and the amine-protecting group being stable under the reaction conditions. The synthetic utility of the product has also been demonstrated, with several common transformations of the aryl-substituted pyrrole product being conducted. This protocol will offer the opportunity to explore other metal-catalyzed cross-coupling reactions employing SEM-protected pyrroles.

Nano-copper catalysed highly regioselective synthesis of 2,4-disubstituted pyrroles from terminal alkynes and isocyanides

Nano-copper(0) stabilized on alumina prepared from Cu-Al hydrotalcite has been reported for completely regioselective synthesis of 2,4-disubstituted pyrroles from unactivated terminal aromatic/aliphatic alkynes and isocyanides. The reaction is operational

Conversion of 4-oxoproline esters to 4-substituted pyrrole-2-carboxylic acid esters

The Grignard, Wittig, Tebbe, Horner-Emmons, and Reformatsky reactions of the 4-oxoproline esters gave the corresponding 4-alylated or 4-alkylidenated products, respectively. The products were properly treated with bases to cause aromatization, giving 4-su