18370-10-0

Basic information

• Product Name: 3-Chloro-N-methylbenzamide ,98%
• Synonyms: 3-Chloro-N-methylbenzamide ,98%;3-Chloro-N-MethylbenzaMide, 97%;BenzaMide, 3-chloro-N-Methyl-
• CAS NO: 18370-10-0
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• Mol File: 18370-10-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Chloro-N-methylbenzamide ,98%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-N-methylbenzamide ,98%(18370-10-0)
• EPA Substance Registry System: 3-Chloro-N-methylbenzamide ,98%(18370-10-0)

Safety Data

• Statements: 20/22-36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 18370-10-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Upstream product

• 109-09-1 2-chloropyridine 
• 108-18-9 diisopropylamine 
• 145959-21-3 3-chloro-N-methoxy-N-methylbenzamide 
• 593-51-1 methylamine hydrochloride 
• 535-80-8 3-chlorobenzoate 
• 67-56-1 methanol 
• 34158-71-9 3-chlorobenzaldehyde oxime 
• 766-84-7 3-chloro-benzonitrile 
• 74-89-5 methylamine 
• 618-48-4 3-chlorobenzamide 
• 30004-67-2 N,S-dimethyl-S-phenylsulfoximine 
• 587-04-2 m-Chlorobenzaldehyde 
• 618-46-2 m-Chlorobenzoyl chloride 
• 832695-88-2 3-(methylcarbamoyl)phenylboronic acid 

Downstream Products

• 1235478-95-1 7-methoxy-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1403951-57-4 7-chloro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1016-78-0 3-chlorobenzophenone 
• 102-54-5 ferrocene 
• 755037-03-7 regorafenib 
• 284461-73-0 sorafenib 
• 1613320-03-8 4-chloro-2-(methylcarbamoyl)phenyl 4-chlorobenzoate 

Relevant articles and documents

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Catalytic asymmetric [3+2] cycloaddition of isomünchnones with methyleneindolinones

An efficient enantioselective [3+2] cycloaddition of isomünchnones with methyleneindolinones that are generated by anin situintramolecular addition of the carbonyl group to rhodium carbenes is realized with a chiralN,N′-dioxide/Zn(ii) complex as a Lewis acid. A series of chiral oxa-bridged 3-spiropiperidines are obtained in high yields with excellent dr and excellent ee values.

Formation of Aryl [1-Cyano-4-(dialkylamino)butadienyl] Ketones from Pyridines

Treatment of 2-chloropyridine with LDA and the Weinreb amide of benzoic acid afforded three unusual products, namely N -methylbenzamide, 2-chloropyridine-3-methanol, and the ring-opened addition product. This same final product could also be obtained from 2-chloro-3-benzoylpyridine on treatment with LDA. Mechanistic insight for the formation of these products is provided.