40783-78-6

Upstream product

• 79-22-1 methyl chloroformate 
• 95-55-6 2-amino-phenol 
• 67-56-1 methanol 
• 107840-19-7 C₁₃H₁₆N₂O₃ 
• 2603-10-3 N-phenyl methyl carbamate 
• 62-53-3 aniline 
• 41064-78-2 N(hydroxy-2 phenyl) carbamate de phenyle 

Relevant academic research and scientific papers

C(sp3)-H Monoarylation of Methanol Enabled by a Bidentate Auxiliary

With the assistance of a practical directing group (COAQ), the first catalytic protocol for the palladium-catalyzed C(sp3)-H monoarylation of methanol has been developed, offering an invaluable synthesis means to establish extensive derivatives of crucial arylmethanol functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional group compatibility, and even the practical synthesis of medicines further demonstrate the usefulness of this strategy.

Palladium catalyzed Csp2-H activation for direct aryl hydroxylation: The unprecedented role of 1,4-dioxane as a source of hydroxyl radicals

A novel strategy for direct aryl hydroxylation via Pd-catalysed Csp2-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups.

Indium-catalyzed reaction for the synthesis of carbamates and carbonates: selective protection of amino groups

We developed a simple, efficient, and selective method for preparing organic carbamates and carbonates using a catalytic amount of indium. A wide range of carbamates and carbonates were synthesized in high yields. The method is also applicable to the selective protection of amino groups under mild conditions.

Synthesis of carbamate derivatives of 2,3-dihydro-4H-1,4-benzoxazine

Alkylation of methyl 2-hydroxyphenylcarbamates with 1,2-dibromoethane in acetone in the presence of K2CO3 gave the corresponding methyl 6(7)-R-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate. Alkylation of methyl 2-hydroxyphenylcarbamat

HYDROXYLATION DIRECTE D'ESTERS DE PHENYLE ET D'ANILIDES PAR LE PEROXYDE D'HYDROGENE EN MILIEU SUPERACIDE

In SbF5-HF, hydrogen peroxide reacts on the aromatic ring of esters 1a-5a and anilides 11a-15a to give monohydroxylated derivatives in good yields.With compounds 2a, 4a and 5a, meta or para isomers are by far the major products, whereas with formate 1a and benzoate 3a, the proportion of the ortho isomer is more important.With anilides, the reaction is less selective, the three isomers being obtained in comparable amounts.Thus, the relative proportions of ortho, meta and para-hydroxylated derivatives obtained using 70 percent H2O2 with acetate 2a and acetanilide 12a are 6/51/43 and 36.5/30/33.5, respectively.The important proportion of meta hydroxylation is the result of the reaction of protonated hydrogen peroxide H3O2+ on the protonated substrate.

DYE SENSITIZED PHOTOOXYGENATION OF SUBSTITUTE OXIME CARBAMATES

Solvolytic cleavage of oxime carbamates can be achieved by dye sensitized photooxygenation.A study with substituted oxime carbamates has revealed an unusual chemoselectivity of singlet oxygen towards carbon-nitrogen single bonds in preference over carbon-nitrogen double bonds in such compounds.