40808-21-7

Upstream product

• 51335-91-2 1-[5-(4-methylphenyl)thiophene-2-yl]ethanone 
• 38401-68-2 5-(4-methylphenyl)thiophene-2-carbaldehyde 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 5720-05-8 4-methylphenylboronic acid 
• 16939-04-1 2-p-tolylthiophene 
• 108-88-3 toluene 
• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 50971-49-8 5-(4-methylphenyl)thiophene-2-carboxylic acid methyl ester 
• 38425-26-2 4-chloro-1-(4-methylphenyl)butan-1-one 

Downstream Products

• 61100-11-6 ethyl 5-(p-tolyl) thiophene-2-carboxylate 
• 845753-53-9 2-bromo-5-(4-methylphenyl)thiophene 

Relevant academic research and scientific papers

Hedgehog signal pathway inhibitor

The invention provides a Hedgehog signal pathway inhibitor as well as stereoisomers, tautomers, hydrates, solvates or pharmaceutically acceptable salts thereof, and the structural formula of the inhibitor is as shown in a formula (I). The invention further provides a preparation method and application of a compound. The compound provided by the invention is novel in structure; a signal transduction pathway adjusted by Hedgehog protein, Ptch, Gli and/or Smo can be adjusted through the compound of the formula I.

An improved protocol for ligandless Suzuki-Miyaura coupling in water

Using a reverse order of addition of reagents, PdCl2 and Pd(OAc)2 are efficient catalysts for the Suzuki-Miyaura reactions in water. The ligandless and mild conditions, the high stability of the catalytic system, short reaction time and good to excellent yields are important features of this protocol.

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.