40819-28-1

Usage

Uses

Used in Pharmaceutical Synthesis:
O-Bromomethylbenzoyl bromide is used as an intermediate in the synthesis of pharmaceuticals. Its reactivity allows for the creation of new compounds that can be further utilized in the development of medications.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical industry, O-Bromomethylbenzoyl bromide is employed as an intermediate for the synthesis of various agrochemicals, contributing to the development of products for agricultural applications.
Used in Organic Synthesis:
O-Bromomethylbenzoyl bromide is used as a reagent in organic synthesis for the preparation of benzophenone-derived compounds. Its ability to form new bonds with nucleophiles makes it a valuable component in creating complex organic molecules.
Used in Research and Development:
In research settings, O-Bromomethylbenzoyl bromide is utilized for exploring new chemical reactions and bonding mechanisms, furthering the understanding of organic chemistry and potentially leading to new discoveries in material and pharmaceutical sciences.

InChI:InChI=1/C8H6Br2O/c9-5-6-3-1-2-4-7(6)8(10)11/h1-4H,5H2

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 7726-95-6 bromine 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 7115-91-5 2-ethoxycarbonylbenzyl bromide 
• 90-44-8 anthracen-9(10H)-one 
• 40819-11-2 3-(benzyl-methyl-amino)-1H-benzo[e][1,3]thiazepin-5-one 
• 115975-25-2 C₁₄H₁₇BrO₃ 
• 115975-25-2 C₁₄H₁₇BrO₃ 
• 115975-22-9 C₁₂H₁₃BrO₃ 
• 186132-73-0 2-Bromomethyl-benzoic acid 4-nitro-benzyl ester 
• 40819-23-6 2,2,2a-triphenyl-2,2a-dihydro-4H-benzo[e]azeto[2,1-b][1,3]thiazepine-1,9-dione 
• 40819-24-7 2a-dimethylamino-2,2-diphenyl-2,2a-dihydro-4H-azeto[2,1-b]benzo[e][1,3]thiazepine-1,9-dione 
• 408535-88-6 (2-methoxymethyl-phenyl)-acetonitrile 
• 171055-42-8 2-methoxymethylbenzyl bromide 
• 68718-99-0 α-chloro-α'-methoxy-o-xylene 
• 62172-88-7 2-(methoxymethyl)-benzyl alcohol 

Relevant academic research and scientific papers

Complete 1H and 13C NMR spectral assignment of benzo[d]isothiazole derivatives and of an isoindole isoster

The complete 1H and 13C NMR assignments of the novel compoundmethyl 2-amino-3-(benzo[d]isothiazol-3-yl)propanoate (1), of 3-amino-5-methylbenzo[d]isothiazole (2) and N-(t-butyloxycarbonyl)-2- aminobenzo[d]isothiazol-3(2H)-one (3) and

184. Total synthesis of cyclothialidine

A total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described The synthetic concept was tested by preparing the lactone 13 (Scheme 2) which contains the characteristic bicyclic core entity of 1. Key features of the synthesis of 1 are: preparation of 3,5-dihydroxy-2,6-dimethylbenzoic acid (23) from 3,5-dihydroxybenzoic acid (19) by two consecutive Mannich aminomethylation/hydrogenation sequences; benzylic N-bromosuccinimide bromination of an ester derivative 25 thereof and its subsequent coupling with Boc-Ser-Cys-OMe (11); cyclization of the ω-hydroxy acid 29 to the 12-membered lactone 30 using preferably Mitsunobu conditions; completion of the peptidic side chains of 1 using Boc strategy (Scheme 4) Optically pure cis-N-(tert-butoxycarbonyl)-3-hydroxy-L-proline ((-)-14) was obtained by resolution of the racemate via an efficient reaction sequence containing a lipase-catalyzed enantiospecific acetate hydrolysis (Scheme 3). The structure of natural 1 was confirmed by comparison with the synthetic material. The synthetic route described provides also easy access to analogues of 1, e.g., via the intermediate 30.