40849-07-8Relevant articles and documents
SYNTHESES OF 4-HYDROXYMETHYL-1(2H)-PHTALAZINONE AND ITS ANALOGS.
Ishikawa, Masayuki,Eguchi, Yukuo
, p. 25 - 30 (2007/10/02)
4-Hydroxymethyl-1(2H)-phthalazinone (2) was preferably prepared by reduction of 4-ethoxycarbonyl-1(2H)-phtalazinone with NaBH4 in EtOH in good yield.The synthetic method was applicable for the preparation of 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone and its 2-phenyl derivative, where the regioselective reduction of the ester at the position 4 was possible, leaving the ester at the position 7 intact.The Grignard reaction of 4-ethoxycarbonyl-1(2H)-phthalazinone was also described.