40862-12-2Relevant academic research and scientific papers
Substituted cycloalkyls as inhibitors of a beta protein production
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, (2008/06/13)
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
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, (2008/06/13)
Disclosed herein is a process for preparing (S)-α-amino-1-carboxycyclopentaneacetic acid which is a useful intermediate for preparing peptidomimetic inhibitors of herpes viral ribonucleotide reductase. The process comprises the preparation of the key intermediate STR1 and its subsequent conversion to the desired product.
An enantioselective synthesis of cyclopentyl-l-aspartic acid amenable to large scale
Moss, Neil,Ferland, Jean-Marie,Goulet, Sylvie,Guse, Ingrid,Malenfant, Eric,Plamondon, Louis,Plante, Raymond,Déziel, Robert
, p. 32 - 34 (2007/10/03)
A new enantioselective synthesis of cyclopentyl-L-aspartic acid [(S)α-amino-1-(carboxy)cyclopentaneacetic acid] (1) and its N-Boc derivative 2 has been developed. This synthesis is amenable to kilogram scale preparation and avoids low temperature reactions and column chromatography.
