40871-00-9

Basic information

• Product Name: Methyl 3-(benzylaMino)butanoate
• Synonyms: Methyl 3-(benzylaMino)butanoate
• CAS NO: 40871-00-9
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.26888
• Mol File: 40871-00-9.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 3-(benzylaMino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(benzylaMino)butanoate(40871-00-9)
• EPA Substance Registry System: Methyl 3-(benzylaMino)butanoate(40871-00-9)

Safety Data

• Hazardous Substances Data: 40871-00-9(Hazardous Substances Data)

Usage

Uses

Methyl 3-(benzylamino)butanoate is a useful chemical in the synthesis process for piperidines by iridium-catalyzed cyclocondensation.

Upstream product

• 623-43-8 crotonic acid methyl ester 
• 14856-79-2 N-benzyl(trimethylsilyl)amine 
• 67-56-1 methanol 
• 100-52-7 benzaldehyde 
• 5303-65-1 (S)-ethyl 3-aminobutyrate 
• 105-45-3 acetoacetic acid methyl ester 
• 100-46-9 benzylamine 
• 623-43-8 methyl crotonate 
• 507444-65-7 methyl 3-(benzylamino)butanoate 
• 134430-97-0 methyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)butanoate 
• 6078-06-4 (R)-methyl 3-aminobutanoate hydrochloride 
• 109299-92-5 3-((E)-but-2-enoyl)oxazolidin-2-one 
• 105754-29-8 Benzylammonium-trifluormethansulfonat 
• 186581-53-3 diazomethane 

Downstream Products

• 119645-17-9 Benzyl-((E)-3-methoxy-1-methyl-3-trimethylsilanyloxy-allyl)-trimethylsilanyl-amine 
• 98014-60-9 tert-butyl N-benzyl-N-(1-methyl-3-oxopropyl)carbamate 
• 113709-39-0 methyl 3-(benzylamino)-2-methylbutanoate 

Relevant articles and documents

Solvent engineering: an effective tool to direct chemoselectivity in a lipase-catalyzed Michael addition

A solvent engineering strategy was implemented in order to control the chemoselectivity in a lipase-catalyzed Michael addition reaction. This strategy was revealed as a high-effective tool for the selective synthesis of Michael adduct 3 or aminolysis product 4 from benzylamine 1 and methyl crotonate 2. Chemoselectivity of the enzymatic process was elucidated in terms of polarity of the medium, hence, adduct 3 was preferentially accumulated in hydrophobic medium, whereas in polar solvents the amide 4 was preferentially formed.

TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE INHIBITORS OF ATR KINASE

The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Mechanochemical enzymatic resolution of N-benzylated-β3-amino esters

The use of mechanochemistry to carry out enantioselective reactions has been explored in the last ten years with excellent results. Several chiral organocatalysts and even enzymes have proved to be resistant to milling conditions, which allows for rather efficient enantioselective transformations under ball-milling conditions. The present article reports the first example of a liquid-assisted grinding (LAG) mechanochemical enzymatic resolution of racemic β3-amino esters employing Candida antarctica lipase B (CALB) to afford highly valuable enantioenriched N-benzylated-β3-amino acids in good yields. Furthermore the present protocol is readily scalable.