99110-76-6

Upstream product

• 99110-77-7 N,N,N-tris<2-(3-benzyloxy-2-oxo-1,2-dihydropyridin-1-yl)acetamido>ethylamine 
• 4097-89-6 2,2',2''-triaminotriethylamine 
• 95215-72-8 2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid 
• 19365-03-8 2-(3-hydroxy-2-oxopyridin-1(2H)-yl)acetic acid 
• 84719-32-4 3-Hydroxy-2(1H)-pyridinone 
• 95215-73-9 3-(benzyloxy)-1-<<(succinimidyloxy)carbonyl>methyl>-2(1H)-pyridinone 
• 95215-70-6 1-ethoxycarbonylmethyl-3-hydroxy pyrid-2-one 

Relevant academic research and scientific papers

Synthesis, physico-chemical and iron(III)-chelating properties of novel hexadentate 3-hydroxy-2(1H)pyridinone ligands

Synthesis of hexadentate ligands via the in situ formation of 1-hydroxy benzotriazolyl active ester in the presence of 2-(1H-benzotriazol-1-yl)- 1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU as a coupling agent is described. The pKa values and distri

Synthetic studies into 3-hydroxy-2(1)-pyridinone based hexadentate metal(III) ion chelators

An improved synthesis and purification of the hexadentate chelators, N,N,N,-tris[2-(3-hydroxy-2-oxo-1,2-dihydropyridin-1-yl)acetamido]ethylamine, 8a and N,N,N,-tris[2-(3-hydroxy-4-methyl-2-oxo-1,2-dihydropyridin-1- yl)acetamido]ethylamine, 8b is described.

Novel 3-hydroxy-2(1H)-pyridinones. Synthesis, iron(III)-chelating properties, and biological activity

The synthesis of a range of novel bidentate and hexadentate ligands containing the chelating moiety 3-hydroxy-2(1H)-pyridinone is described. The pK(a) values of the ligands and the stability constants of their iron(III) complexes have been determined. The stability constant of the iron(III) complex of one of the hexadentate ligands is comparable to that of desferrioxamine B. The distribution coefficients of the ligands and their iron(III) complexes were also determined. One of the novel hexadentate compounds has been shown to markedly enhance iron(III) excretion from both hepatocytes and iron-overloaded mice.

Pharmaceutical compositions of hydroxypyridones

Compounds in which two or more rings, being a 3-hydroxypypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.