41003-95-6

Upstream product

• 52322-57-3 N-(Formylaminomethyl)trimethylammoniumiodid 
• 122-52-1 triethyl phosphite 
• 1066-51-9 Aminomethylphosphonic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 33512-26-4 diethyl (phthalimidomethyl)phosphonate 
• 64-18-6 formic acid 
• 50917-72-1 aminomethylphosphonic acid diethyl ester 

Downstream Products

• 41003-94-5 diethyl isocyanomethylphosphonate 
• 345291-01-2 (2-Hydroxy-2-phenyl-1-pyrrol-1-yl-ethyl)-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme

Installation of olefins into molecules is a key transformation in organic synthesis. The recently discovered decarboxylation-assisted olefination in the biosynthesis of rhabduscin by a mononuclear non-heme iron enzyme (P.IsnB) represents a novel approach in olefin construction. This method is commonly employed in natural product biosynthesis. Herein, we demonstrate that a ferryl intermediate is used for C-H activation at the benzylic position of the substrate. We further establish that P.IsnB reactivity can be switched from olefination to hydroxylation using electron-withdrawing groups appended on the phenyl moiety of the analogues. These experimental observations imply that a pathway involving an initial C-H activation followed by a benzylic carbocation species or by electron transfer coupled β-scission is likely utilized to complete C=C bond formation.

A Facile Conversion of Aminoalkanephosphonic Acids into Their Diethyl Esters. The Use of Unblocked Aminoalkanephosphonic Acids in Phosphono Peptide Synthesis

A simple and efficient, two-step procedure for the preparation of diethyl aminoalkylphosphonates from aminoalkylphosphonic acids is reported.The obtained esters are useful as substrates in phosphono peptide synthesis.

Method for preparation of N-phosphonomethylglycine

A method for the production of N-phosphonomethylglycine is disclosed which comprises the steps of: (a) reacting formaldehyde with formamide at a pH of 9-10 to form N-(hydroxymethyl)formamide, (b) reacting N-(hydroxymethylformamide with triethylphosphite to form diethyl, N-(formyl)aminomethylphosphonate, (c) reacting diethyl, N-(formyl)aminomethylphosphonate with methylchloroacetate to form N-(diethylphosphonomethyl), N-(formyl)glycinemethyl ester, and (d) reacting N-(diethylphosphonomethyl), N-(formyl)glycinemethyl ester with hydrochloric acid to form N-phosphonomethylglycine.