410074-36-1

Upstream product

• 141-32-2 acrylic acid n-butyl ester 
• 577-19-5 2-nitrophenyl bromide 
• 552-16-9 ortho-nitrobenzoic acid 
• 88-73-3 2-Chloronitrobenzene 
• 552-89-6 2-nitro-benzaldehyde 
• 609-73-4 o-nitroiodobenzene 
• 15163-59-4 potassium o-nitrobenzoate 
• 15898-45-0 sodium 2-nitrobenzenesulfinate 
• 98-95-3 nitrobenzene 

Relevant academic research and scientific papers

Palladium/tetraphosphine catalysed Heck reaction with ortho-substituted aryl bromides

The tetraphosphine cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane associated to [PdCl(C3H5)]2 catalyses the Heck reaction of butyl acrylate with a wide range of sterically demanding aryl bromides, furnis

Highly active homoleptic nickel(II) bis-N-heterocyclic carbene catalyst for Suzuki–Miyaura and Heck cross-coupling reactions

New homoleptic nickel(II) biscarbene complex was synthesized and structurally characterized. The complex depicted the excellent catalytic activities with only 3 mol% catalyst loading along with wide substrate scope for the Suzuki–Miyaura cross-coupling reactions (twenty six examples) and Heck coupling reactions (eighteen examples).

Compositions containing ionic liquids and their uses, in particular in organic synthesis

An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A1+X1?, A1+ representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X1? an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.

Novel isoxazoline ligand with ferrocene backbone: Preparation and application in Heck reaction with water as solvent

Two novel isoxazoline N,N-bidentate ligands with ferrocene backbone have been synthesized and employed for the palladium-catalyzed Heck coupling reaction. Among them, 1,3-bis-(5-ferrocenylisoxazoline-3-yl)benzene was found to be thermally stable and a highly effective ligand for Heck coupling reaction in neat water without N2 protection, affording the desired coupling products in good to excellent yield with high diastereoselectivity. The developed catalytic system was also well workable for 1,2-disubstituted alkenes, which were less involved in the Heck reaction for its larger steric hindrance. Copyright

2-Hydroxy-1,10-phenanthroline vs 1,10-Phenanthroline: Significant ligand acceleration effects in the Palladium-Catalyzed Oxidative Heck reaction of arenes

A series of bidentate monoanionic nitrogen ligands were designed and applied in the Pd-catalyzed oxidative Heck reaction of arenes with alkenes. Significant ligand-accelerated effects were observed, and direct C-H functionalized products were formed in high yields with meta-selectivity.

Pd-catalyzed ligand-free desulfitative Heck reaction with arenesulfinic acid salts under air

Palladium-catalyzed cross-coupling reactions of various aryl sulfinic acid salts with a wide variety of vinyl substrates have been achieved in good to excellent yields under simple aerobic conditions at 70°C with the assistance of Cu(II) salts. The reaction can be accelerated by the combination of DMSO with THF. The reported Matsuda-Heck type coupling reactions are tolerant to the common functional groups, making these transformations as attractive alternatives to the traditional cross-coupling approaches. Copyright

A novel N-O ligand for palladium-catalyzed Mizoroki-Heck reaction in neat water

1-(Morpholin-1-yl-pyridin-2-yl-methyl)-2-naphthol as a novel efficient N-O ligand has been developed for palladium-catalyzed Mizoroki-Heck reaction in neat water without the protection of an inert atmosphere. The reactions proceed smoothly and give the desired products in moderate to excellent yields. The catalyst system is reusable.

Ligand-free copper-catalyzed arylation of olefins by the mizoroki-heck reaction

A novel ligand-free copper-catalyzed Mizoroki-Heck cross-coupling reaction of various aryl iodides with olefins has been developed. Both the solvent and the base were found to have a fundamental influence on the efficiency of the transformation in the presence of 10 mol% Cu, with DMF and tetramethylammonium bromide (TMAB) being the optimal solvent and base, respectively. As a result, a set of the corresponding E-internal olefins were obtained selectively in moderate to good yields.

Pd-catalyzed decarboxylative Heck vinylation of 2-nitrobenzoates in the presence of CuF2

A new protocol for the decarboxylative Heck vinylation of benzoic acids is disclosed. In the presence of a catalyst system generated in situ from Pd(OAc)2 (2 mol %), CuF2 (2 equiv), and benzoquinone (0.5 equiv) in NMP, a wide range of olefins were coupled with various 2-nitrobenzoates at 130 °C with the release of carbon dioxide to afford the corresponding vinyl arenes in good yields.

Efficient polymer-supported Pd catalysts for the heck reaction

Some efficient polymer-supported palladium catalysts have been synthesized. Their catalytic effects were evaluated in the Heck reaction of iodobenzene with acrylates or styrene. High catalytic activities were achieved with turn over frequencies (TOF) up to 28000 and 6250, respectively. For the reaction of iodobenzene with styrene, high stereoselectivity was obtained. Additionally, the catalysts could be recovered by a simple filtration progress and can be reused for at least 5 times with a slow progressive decrease in activity.