41010-06-4

Upstream product

• 951247-74-8 C₁₁H₁₆O₃S 
• 151-50-8 potassium cyanide 
• 14902-36-4 3-(2-methylphenyl)-1-propanol 
• 89-95-2 2-methyl-benzyl alcohol 
• 107-13-1 acrylonitrile 
• 529-20-4 2-methylphenyl aldehyde 
• 22084-89-5 3-(2-methylphenyl)propanoic acid 
• 2373-76-4 2-methylcinnamic acid 
• 7029-31-4 bis(2-methylphenyl)zinc 
• 1587-04-8 1-methyl-2-(2-propenyl)-benzene 

Downstream Products

• 6943-79-9 4-(2-methylphenyl)butanoic acid 
• 6939-35-1 5-methyl-1-tetralone 
• 859809-70-4 4-o-tolyl-butyryl chloride 

Relevant academic research and scientific papers

Divergent Nickel-Catalysed Ring-Opening-Functionalisation of Cyclobutanone Oximes with Organozincs

The development of a nickel-catalysed strategy for the remote alkylation, arylation, vinylation and alkynylation of nitriles is presented. The methodology uses electron-poor O-Ar cyclic oximes and organozincs as coupling partners. This redox process proceeds through the generation of an iminyl radical and its following ring-opening reaction.

Cooperative Palladium/Lewis Acid-Catalyzed Transfer Hydrocyanation of Alkenes and Alkynes Using 1-Methylcyclohexa-2,5-diene-1-carbonitrile

Catalytic transfer hydrocyanation represents a clean and safe alternative to hydrocyanation processes using toxic HCN gas. Such reactions provide access to pharmaceutically important nitrile derivatives starting with alkenes and alkynes. Herein, an efficient and practical cooperative palladium/Lewis acid-catalyzed transfer hydrocyanation of alkenes and alkynes is presented using 1-methylcyclohexa-2,5-diene-1-carbonitrile as a benign and readily available HCN source. A large set of nitrile derivatives (>50 examples) are prepared from both aliphatic and aromatic alkenes with good to excellent anti-Markovnikov selectivity. A range of aliphatic alkenes engage in selective hydrocyanation to provide the corresponding nitriles. The introduced method is useful for chain walking hydrocyanation of internal alkenes to afford terminal nitriles in good regioselectivities. This protocol is also applicable to late-stage modification of bioactive molecules.

Low-Valent Titanium-Mediated Radical Conjugate Addition Using Benzyl Alcohols as Benzyl Radical Sources

A concise method to directly generate benzyl radicals from benzyl alcohol derivatives has been developed. The simple and inexpensive combination of TiCl4(collidine) (collidine = 2,4,6-collidine) and manganese powder afforded a low-valent titanium reagent, which facilitated homolytic cleavage of benzylic C-OH bonds. The application to radical conjugate addition reactions demonstrated the broad scope of this method. The reaction of various benzyl alcohol derivatives with electron-deficient alkenes furnished the corresponding radical adducts.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.